A reciprocating motion-driven rotation mechanism for the ATP synthase

doi:10.1007/s11427-015-4995-0

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	A reciprocating motion-driven rotation mechanism for the ATP synthase
	Liu, Jiafeng ; Fu, Xinmiao ; Chang, Zengyi
刊名	SCIENCE CHINA-LIFE SCIENCES
	2016
关键词	ATP synthase rotational catalysis rotary model INTERSUBUNIT ROTATION GAMMA-SUBUNIT ROTOR RING F-ATPASE RESOLUTION MITOCHONDRIA F-1-ATPASE CATALYSIS F1-ATPASE MOLECULE
DOI	10.1007/s11427-015-4995-0
英文摘要	The ATP synthase (having a typical subunit composition of alpha(3)beta gamma delta epsilon ab(2)c(8-15)) employs an intriguing rotary mechanism for the generation of ATP from ADP and Pi, using energy stored in a transmembrane proton gradient. The conventional rotary model, although being generally accepted, remains difficult to explain certain experimental observations. Here we propose an alternative rotary model for the ATP synthase such that what rotates is the catalytic alpha(3)beta(3) cylinder rather than the central stalk and the membrane-embedded c-ring. Specifically, the membrane translocation of protons would induce a cycled conformational change in the c-ring, leading to a reciprocating motion of the attached central stalk, which in turn drives the unidirectional rotation of the alpha(3)beta(3) cylinder. Such a reciprocating motion-driven rotation mechanism is somehow analogous to the working mechanism of a retractable click ballpoint pen. Our new model not only explains the experimental observations that have been difficult to reconcile with the conventional model but also avoids its theoretical illogicality.; National Basic Research Program of China [2012CB917300]; National Natural Science Foundation of China [31470766, 31170738, 31270804, 31570778]; SCI(E); PubMed; 中国科学引文数据库(CSCD); ARTICLE; fuxinmiao@pku.edu.cn; changzy@pku.edu.cn; 1; 44-48; 59
语种	中文
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/435566]
专题	生命科学学院
推荐引用方式 GB/T 7714	Liu, Jiafeng,Fu, Xinmiao,Chang, Zengyi. A reciprocating motion-driven rotation mechanism for the ATP synthase[J]. SCIENCE CHINA-LIFE SCIENCES,2016.
APA	Liu, Jiafeng,Fu, Xinmiao,&Chang, Zengyi.(2016).A reciprocating motion-driven rotation mechanism for the ATP synthase.SCIENCE CHINA-LIFE SCIENCES.
MLA	Liu, Jiafeng,et al."A reciprocating motion-driven rotation mechanism for the ATP synthase".SCIENCE CHINA-LIFE SCIENCES (2016).