GluR2-3Y Inhibits the Acquisition and Reinstatement of Morphine-Induced   Conditioned Place Preference in Rats

doi:10.1007/s12264-016-0018-9

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	GluR2-3Y Inhibits the Acquisition and Reinstatement of Morphine-Induced Conditioned Place Preference in Rats
	Lin, Xiao-Jing ; Zhang, Jian-Jun ; Yu, Long-Chuan
刊名	NEUROSCIENCE BULLETIN
	2016
关键词	GluR2-3Y AMPA receptors Morphine Conditioned place preference Acquisition of mCPP Reinstatement of mCPP AMPA RECEPTOR ENDOCYTOSIS VENTRAL TEGMENTAL AREA LONG-TERM DEPRESSION BEHAVIORAL SENSITIZATION NUCLEUS-ACCUMBENS PREFRONTAL CORTEX EXPRESSION EXTINCTION ANTAGONIST LY293558
DOI	10.1007/s12264-016-0018-9
英文摘要	Accumulating evidence indicates that alpha-amino-3-hydroxy-5-methylisoxazole-4-propionic acid receptors (AMPARs) are involved in the relapse to abused drugs. However, the role of AMPARs containing the GluR2 subunit in opiate addiction is still unclear. GluR2-3Y, an interfering peptide, prevents the endocytosis of AMPARs containing the GluR2 subunit. In this study, we explored the effect of intravenous injection of GluR2-3Y on the acquisition, expression, and reinstatement of morphine-induced conditioned place preference (mCPP) in rats. We found that infusion of GluR2-3Y (1.5 nmol/g) one hour before morphine during the conditioning phase inhibited the acquisition of mCPP, while an identical injection one hour before the post-conditioning test had no influence on the expression of mCPP. Injection of GluR2-3Y (1.5 nmol/g) after mCPP extinction blocked the morphine-induced reinstatement of mCPP. Our results strongly support the hypothesis that inhibition of AMPAR endocytosis provides a new target for the treatment of opiate addiction.; National Natural Science Foundation of China [81171043, 31400880]; Key Laboratory of Mental Health, Institute of Psychology, Chinese Academy of Sciences, China [KLMH2014ZG02]; SCI(E); PubMed; 中国科技核心期刊(ISTIC); 中国科学引文数据库(CSCD); ARTICLE; yulc@pku.edu.cn; 2; 177-182; 32
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/434712]
专题	生命科学学院
推荐引用方式 GB/T 7714	Lin, Xiao-Jing,Zhang, Jian-Jun,Yu, Long-Chuan. GluR2-3Y Inhibits the Acquisition and Reinstatement of Morphine-Induced Conditioned Place Preference in Rats[J]. NEUROSCIENCE BULLETIN,2016.
APA	Lin, Xiao-Jing,Zhang, Jian-Jun,&Yu, Long-Chuan.(2016).GluR2-3Y Inhibits the Acquisition and Reinstatement of Morphine-Induced Conditioned Place Preference in Rats.NEUROSCIENCE BULLETIN.
MLA	Lin, Xiao-Jing,et al."GluR2-3Y Inhibits the Acquisition and Reinstatement of Morphine-Induced Conditioned Place Preference in Rats".NEUROSCIENCE BULLETIN (2016).