BTG4 is a meiotic cell cycle-coupled maternal-zygotic transition   licensing factor in oocytes

doi:10.1038/nsmb.3204

CORC > 北京大学 > 生命科学学院

	BTG4 is a meiotic cell cycle-coupled maternal-zygotic transition licensing factor in oocytes
	Yu, Chao ; Ji, Shu-Yan ; Sha, Qian-Qian ; Dang, Yujiao ; Zhou, Jian-Jie ; Zhang, Yin-Li ; Liu, Yang ; Wang, Zhong-Wei ; Hu, Boqiang ; Sun, Qing-Yuan ; Sun, Shao-Chen ; Tang, Fuchou ; Fan, Heng-Yu
刊名	NATURE STRUCTURAL & MOLECULAR BIOLOGY
	2016
关键词	CYTOPLASMIC MESSENGER-RNA CCR4-NOT COMPLEX TRANSLATIONAL CONTROL PC3/BTG/TOB FAMILY STRUCTURAL BASIS GENE DEADENYLATION POLYADENYLATION BINDING PROTEIN
DOI	10.1038/nsmb.3204
英文摘要	The mRNAs stored in oocytes undergo general decay during the maternal-zygotic transition (MZT), and their stability is tightly interconnected with meiotic cell-cycle progression. However, the factors that trigger decay of maternal mRNA and couple this event to oocyte meiotic maturation remain elusive. Here, we identified B-cell translocation gene-4 (BTG4) as an MZT licensing factor in mice. BTG4 bridged CNOT7, a catalytic subunit of the CCR4-NOT deadenylase, to elF4E, a key translation initiation factor, and facilitated decay of maternal mRNA. Btg4-null females produced morphologically normal oocytes but were infertile, owing to early developmental arrest. The intrinsic MAP kinase cascade in oocytes triggered translation of Btg4 mRNA stored in fully grown oocytes by targeting the 3' untranslated region, thereby coupling CCR4-NOT deadenylase-mediated decay of maternal mRNA with oocyte maturation and fertilization. This is a key step in oocyte cytoplasmic maturation that determines the developmental potential of mammalian embryos.; National Basic Research Program of China [2012CB944403]; National Natural Science Foundation of China [31528016, 91519313, 31371449]; SCI(E); PubMed; ARTICLE; hyfan@zju.edu.cn; 5; 387-394; 23
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/434168]
专题	生命科学学院
推荐引用方式 GB/T 7714	Yu, Chao,Ji, Shu-Yan,Sha, Qian-Qian,et al. BTG4 is a meiotic cell cycle-coupled maternal-zygotic transition licensing factor in oocytes[J]. NATURE STRUCTURAL & MOLECULAR BIOLOGY,2016.
APA	Yu, Chao.,Ji, Shu-Yan.,Sha, Qian-Qian.,Dang, Yujiao.,Zhou, Jian-Jie.,...&Fan, Heng-Yu.(2016).BTG4 is a meiotic cell cycle-coupled maternal-zygotic transition licensing factor in oocytes.NATURE STRUCTURAL & MOLECULAR BIOLOGY.
MLA	Yu, Chao,et al."BTG4 is a meiotic cell cycle-coupled maternal-zygotic transition licensing factor in oocytes".NATURE STRUCTURAL & MOLECULAR BIOLOGY (2016).