EphB2 in the Medial Prefrontal Cortex Regulates Vulnerability to Stress

doi:10.1038/npp.2016.58

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	EphB2 in the Medial Prefrontal Cortex Regulates Vulnerability to Stress
	Zhang, Ruo-Xi ; Han, Ying ; Chen, Chen ; Xu, Ling-Zhi ; Li, Jia-Li ; Chen, Na ; Sun, Cheng-Yu ; Chen, Wen-Hao ; Zhu, Wei-Li ; Shi, Jie ; Lu, Lin
刊名	NEUROPSYCHOPHARMACOLOGY
	2016
关键词	EphB2 stress vulnerability depression cofilin spine remodeling DENDRITIC SPINE PLASTICITY RETRIEVAL-EXTINCTION PROCEDURE SOCIAL DEFEAT STRESS CHRONIC MILD STRESS SYNAPTIC PLASTICITY SIGNALING PATHWAY ACTIN DYNAMICS COFILIN-PHOSPHORYLATION HIPPOCAMPAL-NEURONS MAJOR DEPRESSION
DOI	10.1038/npp.2016.58
英文摘要	The ephrin B2 (EphB2) receptor is a tyrosine kinase receptor that is associated with synaptic development and maturation. It has recently been implicated in cognitive deficits and anxiety. However, still unknown is the involvement of EphB2 in the vulnerability to stress. In the present study, we observed decreases in EphB2 levels and their downstream molecules in the medial prefrontal cortex (mPFC) but not in the orbitofrontal cortex (OFC) in mice that were susceptible to chronic social defeat stress. The activation of EphB2 receptors with EphrinBI-Fc in the mPFC produced stress-resistant and antidepressant-like behavioral effects in susceptible mice that lasted for at least 10 days. EphB2 receptor knockdown by short-hairpin RNA in the mPFC increased the susceptibility to stress and induced depressive-like behaviors in a subthreshold chronic social defeat stress paradigm. These behavioral effects were associated with changes in the phosphorylation of cofilin and membrane alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR) trafficking and the expression of some synaptic proteins in the mPFC. We also found that EphB2 regulated stress-induced spine remodeling in the mPFC. Altogether, these results indicate that EphB2 is a critical regulator of stress vulnerability and might be a potential target for the treatment of depression.; National Basic Research Program of China [2015CB856400, 2015CB553503]; National Natural Science Foundation of China [31230033, 91432303, 81221002]; SCI(E); CPCI-S(ISTP); PubMed; ARTICLE; 10; 2541-2556; 41
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/434011]
专题	生命科学学院心理与认知科学学院
推荐引用方式 GB/T 7714	Zhang, Ruo-Xi,Han, Ying,Chen, Chen,et al. EphB2 in the Medial Prefrontal Cortex Regulates Vulnerability to Stress[J]. NEUROPSYCHOPHARMACOLOGY,2016.
APA	Zhang, Ruo-Xi.,Han, Ying.,Chen, Chen.,Xu, Ling-Zhi.,Li, Jia-Li.,...&Lu, Lin.(2016).EphB2 in the Medial Prefrontal Cortex Regulates Vulnerability to Stress.NEUROPSYCHOPHARMACOLOGY.
MLA	Zhang, Ruo-Xi,et al."EphB2 in the Medial Prefrontal Cortex Regulates Vulnerability to Stress".NEUROPSYCHOPHARMACOLOGY (2016).