Growth arrest specific gene 7 is associated with schizophrenia and   regulates neuronal migration and morphogenesis

doi:10.1186/s13041-016-0238-y

CORC > 北京大学 > 生命科学学院

	Growth arrest specific gene 7 is associated with schizophrenia and regulates neuronal migration and morphogenesis
	Zhang, Zhengrong ; Zheng, Fanfan ; You, Yang ; Ma, Yuanlin ; Lu, Tianlan ; Yue, Weihua ; Zhang, Dai
刊名	MOLECULAR BRAIN
	2016
关键词	Schizophrenia GAS7 Neurite outgrowth Neuronal migration F-BAR DOMAINS CYTOSKELETAL DYNAMICS MEMBRANE INVAGINATION HIPPOCAMPAL-NEURONS CEREBRAL-CORTEX GAS7 FILOPODIA OUTGROWTH BIPOLAR REORGANIZATION
DOI	10.1186/s13041-016-0238-y
英文摘要	Background: Schizophrenia is a highly heritable chronic mental disorder with significant abnormalities in brain function. The neurodevelopmental hypothesis proposes that schizophrenia originates in the prenatal period due to impairments in neuronal developmental processes such as migration and arborization, leading to abnormal brain maturation. Previous studies have identified multiple promising candidate genes that drive functions in neurodevelopment and are associated with schizophrenia. However, the molecular mechanisms of how they exert effects on the pathophysiology of schizophrenia remain largely unknown. Results: In our research, we identified growth arrest specific gene 7 (GAS7) as a schizophrenia risk gene in two independent Han Chinese populations using a two-stage association study. Functional experiments were done to further explore the underlying mechanisms of the role of Gas7 in cortical development. In vitro, we discovered that Gas7 contributed to neurite outgrowth through the F-BAR domain. In vivo, overexpression of Gas7 arrested neuronal migration by increasing leading process branching, while suppression of Gas7 could inhibit neuronal migration by lengthening leading processes. Through a series of behavioral tests, we also found that Gas7-deficient mice showed sensorimotor gating deficits. Conclusions: Our results demonstrate GAS7 as a susceptibility gene for schizophrenia. Gas7 might participate in the pathogenesis of schizophrenia by regulating neurite outgrowth and neuronal migration through its C-terminal F-BAR domain. The impaired pre-pulse inhibition (PPI) of Gas7-deficient mice might mirror the disease-related behavior in schizophrenia.; National Science Foundation of China [91232305, 91432304, 81222011]; SCI(E); PubMed; ARTICLE; fanfan.zheng@nlpr.ia.ac.cn; daizhang@bjmu.edu.cn; 1; 54; 9
语种	中文
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/433695]
专题	生命科学学院心理与认知科学学院
推荐引用方式 GB/T 7714	Zhang, Zhengrong,Zheng, Fanfan,You, Yang,et al. Growth arrest specific gene 7 is associated with schizophrenia and regulates neuronal migration and morphogenesis[J]. MOLECULAR BRAIN,2016.
APA	Zhang, Zhengrong.,Zheng, Fanfan.,You, Yang.,Ma, Yuanlin.,Lu, Tianlan.,...&Zhang, Dai.(2016).Growth arrest specific gene 7 is associated with schizophrenia and regulates neuronal migration and morphogenesis.MOLECULAR BRAIN.
MLA	Zhang, Zhengrong,et al."Growth arrest specific gene 7 is associated with schizophrenia and regulates neuronal migration and morphogenesis".MOLECULAR BRAIN (2016).