Inhibition of Lactate Transport Erases Drug Memory and Prevents Drug   Relapse

doi:10.1016/j.biopsych.2015.07.007

CORC > 北京大学 > 生命科学学院

	Inhibition of Lactate Transport Erases Drug Memory and Prevents Drug Relapse
	Zhang, Yan ; Xue, Yanxue ; Meng, Shiqiu ; Luo, Yixiao ; Liang, Jie ; Li, Jiali ; Ai, Sizhi ; Sun, Chengyu ; Shen, Haowei ; Zhu, Weili ; Wu, Ping ; Lu, Lin ; Shi, Jie
刊名	BIOLOGICAL PSYCHIATRY
	2016
关键词	Basolateral amygdale Cocaine Lactate transport Reconsolidation Relapse Retrieval LOCAL PROTEIN-SYNTHESIS NUCLEUS-ACCUMBENS CORE FOOTSHOCK-INDUCED REINSTATEMENT CONDITIONED PLACE PREFERENCE COCAINE-SEEKING BEHAVIOR D-SERINE BASOLATERAL AMYGDALA MONOCARBOXYLATE TRANSPORTERS SYNAPTIC PLASTICITY SIGNALING PATHWAY
DOI	10.1016/j.biopsych.2015.07.007
英文摘要	BACKGROUND: Drug memories that associate drug-paired stimuli with the effects of abused drugs contribute to relapse. Exposure to drug-associated contexts causes consolidated drug memories to be in a labile state, during which manipulations can be given to impair drug memories. Although substantial evidence demonstrates the crucial role of neuronal signaling in addiction, little is known about the contribution of astrocyte-neuron communication. METHODS: Rats were trained for cocaine-induced conditioned place preference (CPP) or self-administration and microinjected with the glycogen phosphorylation inhibitor 1,4-dideoxy-1,4-imino-D-arabinitol into the basolateral amygdala (BLA) immediately after retrieval. The concentration of lactate was measured immediately after retrieval via microdialysis, and the CPP score and number of nosepokes were recorded 24 hours later. Furthermore, we used antisense oligodeoxynucleotides to disrupt the expression of astrocytic lactate transporters (monocarboxylate transporters 1 and 2) in the BLA after retrieval, tested the expression of CPP 1 day later, and injected L-lactate into the BLA 15 minutes before retrieval to rescue the effects of the oligodeoxynucleotides. RESULTS: Injection of 1,4-dideoxy-1,4-imino-D-arabinitol into the BLA immediately after retrieval prevented the subsequent expression of cocaine-induced CPP, decreased the concentration of lactate in the BLA, and reduced the number of nosepokes for cocaine self-administration. Disrupting the expression of monocarboxylate transporters 1 and 2 in the BLA also caused subsequent deficits in the expression of cocaine-induced CPP, which was rescued by pretreatment with L-lactate. CONCLUSIONS: Our results suggest that astrocyte-neuron lactate transport in the BLA is critical for the reconsolidation of cocaine memory.; Natural Science Foundation of China [81225009, 31230033, 81221002, U1402226]; National Basic Research Program of China [2015CB553503, 2015CB8586400]; SCI(E); PubMed; ARTICLE; shijie@bjmu.edu.cn; 11; 928-939; 79
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/418350]
专题	生命科学学院
推荐引用方式 GB/T 7714	Zhang, Yan,Xue, Yanxue,Meng, Shiqiu,et al. Inhibition of Lactate Transport Erases Drug Memory and Prevents Drug Relapse[J]. BIOLOGICAL PSYCHIATRY,2016.
APA	Zhang, Yan.,Xue, Yanxue.,Meng, Shiqiu.,Luo, Yixiao.,Liang, Jie.,...&Shi, Jie.(2016).Inhibition of Lactate Transport Erases Drug Memory and Prevents Drug Relapse.BIOLOGICAL PSYCHIATRY.
MLA	Zhang, Yan,et al."Inhibition of Lactate Transport Erases Drug Memory and Prevents Drug Relapse".BIOLOGICAL PSYCHIATRY (2016).