NDUFV2 regulates neuronal migration in the developing cerebral cortex   through modulation of the multipolar-bipolar transition

doi:10.1016/j.brainres.2015.08.028

CORC > 北京大学 > 生命科学学院

	NDUFV2 regulates neuronal migration in the developing cerebral cortex through modulation of the multipolar-bipolar transition
	Chen, Tianda ; Wu, Qinwei ; Zhang, Yang ; Zhang, Dai
刊名	BRAIN RESEARCH
	2015
关键词	Developing cerebral cortex Neuronal migration In utero Electroporation NDUFV2 MITOCHONDRIAL COMPLEX-I SUBUNIT GENE NDUFV2 PARKINSONS-DISEASE LYMPHOBLASTOID-CELLS SCHIZOPHRENIA DISORDER ASSOCIATION EXPRESSION 18P11 CARDIOMYOPATHY
DOI	10.1016/j.brainres.2015.08.028
英文摘要	Abnormalities during brain development are tightly linked several psychiatric disorders. Mutations in NADH dehydrogenase ubiquinone flavoprotein 2 (NDUFV2) are responsible for schizophrenia, bipolar disorder and Parkinson's disease. However, the function of NDUFV2 during brain development remains unclear. Here we reported that ndufu2 is expressed in the developing cerebral cortex. In utero suppression of ndufu2 arrested neuronal migration, leading to accumulation of ectopic neurons in the intermediate zone. ndufu2 inhibition did not affect radial glia scaffold, progenitor cells or neurons survival. However, the loss of ndufu2 impairs neuronal multipolar-bipolar transition in vivo and polarization in vitro. Moreover, ndufu2 affected actin cytoskeleton and tubulin stabilization in cortical neurons. Overall, our findings establish a new NDUFV2 dependent mechanism underlying neuronal migration and psychiatric disorders. (C) 2015 Elsevier B.V. All rights reserved.; National Natural Science Foundation of China [81401111]; Bejing Natural Science Foundation [7144259]; Specialized Research Fund for the Doctoral Program of Higher Education [20130001120115]; SCI(E); PubMed; ARTICLE; Tiandachen@bjmu.edu.cn; daizhang@bjmu.edu.cn; 102-110; 1625
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/418255]
专题	生命科学学院心理与认知科学学院
推荐引用方式 GB/T 7714	Chen, Tianda,Wu, Qinwei,Zhang, Yang,et al. NDUFV2 regulates neuronal migration in the developing cerebral cortex through modulation of the multipolar-bipolar transition[J]. BRAIN RESEARCH,2015.
APA	Chen, Tianda,Wu, Qinwei,Zhang, Yang,&Zhang, Dai.(2015).NDUFV2 regulates neuronal migration in the developing cerebral cortex through modulation of the multipolar-bipolar transition.BRAIN RESEARCH.
MLA	Chen, Tianda,et al."NDUFV2 regulates neuronal migration in the developing cerebral cortex through modulation of the multipolar-bipolar transition".BRAIN RESEARCH (2015).