From genetic studies to precision medicine in alcohol dependence

doi:10.1097/FBP.0000000000000202

CORC > 北京大学 > 生命科学学院

	From genetic studies to precision medicine in alcohol dependence
	Sun, Yan ; Zhang, Yan ; Wang, Fan ; Sun, Yankun ; Shi, Jie ; Lu, Lin
刊名	BEHAVIOURAL PHARMACOLOGY
	2016
关键词	alcohol dependence environmental factors genetic candidates human precision medicine therapeutic strategy OPIOID RECEPTOR GENE SEROTONIN TRANSPORTER GENE NEUROTROPHIC-FACTOR BDNF GENOME-WIDE ASSOCIATION CATECHOL-O-METHYLTRANSFERASE RANDOMIZED CONTROLLED-TRIAL GAMMA-AMINOBUTYRIC-ACID MONOAMINE-OXIDASE ALDEHYDE DEHYDROGENASE USE DISORDERS
DOI	10.1097/FBP.0000000000000202
英文摘要	Genetic factors contribute to more than 50% of the variation in the vulnerability to alcohol dependence (AD). Although significant advances have been made in medications for AD, these medications do not work for all people. Precise tailoring of medicinal strategies for individual alcoholic patients is needed to achieve optimal outcomes. This review updates the most promising information on genetic variants in AD, which may be useful for improving diagnostic, therapeutic, and monitoring strategies. We describe genetic candidates of various neurotransmitter and enzyme systems. In addition to biological and allelic associations with AD, genetic effects on AD-related phenotypes and treatment responses have also been described. Gene-gene and gene-environment interactions have been considered. Potential applications of genomewide and epigenetic approaches for identifying genetic biomarkers of AD have been discussed. Overall, the application of genetic findings in precision medicine for AD will likely involve an integrated approach that distinguishes effect sizes of specific genetic predictors with regard to sex, pharmacotherapy, ethnicity, and AD-related aspects and considers gene-gene and gene-environment interactions. Our work may pave the way toward more precise treatment for AD that could ultimately improve clinical management and interventions. Copyright (C) 2016 Wolters Kluwer Health, Inc. All rights reserved.; National Basic Research Program of China [2015CB553503, 2015CB856400]; National Natural Science Foundation of China [81221002, U1402226]; National Science Fund [81225009]; SCI(E); PubMed; SSCI; REVIEW; linlu@bjmu.edu.cn; 2-3,SI; 87-99; 27
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/416688]
专题	生命科学学院心理与认知科学学院
推荐引用方式 GB/T 7714	Sun, Yan,Zhang, Yan,Wang, Fan,et al. From genetic studies to precision medicine in alcohol dependence[J]. BEHAVIOURAL PHARMACOLOGY,2016.
APA	Sun, Yan,Zhang, Yan,Wang, Fan,Sun, Yankun,Shi, Jie,&Lu, Lin.(2016).From genetic studies to precision medicine in alcohol dependence.BEHAVIOURAL PHARMACOLOGY.
MLA	Sun, Yan,et al."From genetic studies to precision medicine in alcohol dependence".BEHAVIOURAL PHARMACOLOGY (2016).