Type I Interferons Triggered through the Toll-Like Receptor 3-TRIF   Pathway Control Coxsackievirus A16 Infection in Young Mice

doi:10.1128/JVI.01627-15

CORC > 北京大学 > 生命科学学院

	Type I Interferons Triggered through the Toll-Like Receptor 3-TRIF Pathway Control Coxsackievirus A16 Infection in Young Mice
	Yang, Juhao ; Yang, Chunfu ; Guo, Nining ; Zhu, Kai ; Luo, Kaiming ; Zhang, Na ; Zhao, Hui ; Cui, Ying ; Chen, Lei ; Wang, Hongyang ; Gu, Jun ; Ge, Baoxue ; Qin, Cheng-Feng ; Leng, Qibin
刊名	JOURNAL OF VIROLOGY
	2015
关键词	ENTEROVIRUS 71 MOUTH-DISEASE TAIWAN RESPONSES CELLS HAND FOOT EPIDEMIOLOGY TRANSMISSION EXPRESSION
DOI	10.1128/JVI.01627-15
英文摘要	Coxsackievirus A16 (CVA16) is one of the major etiological agents of hand, foot, and mouth disease (HFMD) in children. The host defense mechanisms against CVA16 infection remain almost entirely unknown. Unlike previous observations with enterovirus 71 (EV71) infection, here we show that gamma interferon (IFN-gamma) or invariant NK T cell deficiency does not affect disease development or the survival of CVA16-infected mice. In contrast, type I interferon receptor deficiency resulted in the development of more severe disease in mice, and the mice had a lower survival rate than wild-type mice. Similarly, a deficiency of Toll-like receptor 3 (TLR3) and TRIF, but not other pattern recognition receptors, led to the decreased survival of CVA16-infected mice. TLR3-TRIF signaling was indispensable for the induction of type I interferons during CVA16 infection in mice and protected young mice from disease caused by the infection. In particular, TRIF-mediated immunity was critical for preventing CVA16 replication in the neuronal system before disease occurred. IFN-beta treatment was also found to compensate for TRIF deficiency in mice and decreased the disease severity in and mortality of CVA16-infected mice. Altogether, type I interferons induced by TLR3-TRIF signaling mediate protective immunity against CVA16 infection. These findings may shed light on therapeutic strategies to combat HFMD caused by CVA16 infection. IMPORTANCE Hand, foot, and mouth disease (HFMD) is a major threat to public health in the Asia-Pacific region. Both CVA16 and EV71 are major pathogens that are responsible for HFMD. The majority of research efforts have focused on the more virulent EV71, but little has been done with CVA16. Thus far, host immune responses to CVA16 infection have not yet been elucidated. The present study discovered an initial molecular mechanism underlying host protective immunity against CVA16 infection, providing the first explanation for why CVA16 and EV71 cause different clinical outcomes upon infection of humans. Therefore, different therapeutic strategies should be developed to treat HFMD cases caused by these two viruses.; National Natural Science Foundation of China [31270951, 81172807]; National Basic Research Program of China [2011CB504903]; Total Foundation; SCI(E); PubMed; ARTICLE; qbleng@sibs.ac.cn; 21; 10860-10867; 89
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/415438]
专题	生命科学学院
推荐引用方式 GB/T 7714	Yang, Juhao,Yang, Chunfu,Guo, Nining,et al. Type I Interferons Triggered through the Toll-Like Receptor 3-TRIF Pathway Control Coxsackievirus A16 Infection in Young Mice[J]. JOURNAL OF VIROLOGY,2015.
APA	Yang, Juhao.,Yang, Chunfu.,Guo, Nining.,Zhu, Kai.,Luo, Kaiming.,...&Leng, Qibin.(2015).Type I Interferons Triggered through the Toll-Like Receptor 3-TRIF Pathway Control Coxsackievirus A16 Infection in Young Mice.JOURNAL OF VIROLOGY.
MLA	Yang, Juhao,et al."Type I Interferons Triggered through the Toll-Like Receptor 3-TRIF Pathway Control Coxsackievirus A16 Infection in Young Mice".JOURNAL OF VIROLOGY (2015).