Retinoic acid-inducible gene-I mediates late phase induction of   TNF-alpha by lipopolysaccharide

CORC > 北京大学 > 生命科学学院

	Retinoic acid-inducible gene-I mediates late phase induction of TNF-alpha by lipopolysaccharide
	Wang, Jing ; Wu, Su ; Jin, Xin ; Li, Mingtao ; Chen, Shiyong ; Teeling, Jessica L. ; Perry, V. Hugh ; Gu, Jun
刊名	journal of immunology
	2008
关键词	DOUBLE-STRANDED-RNA NF-KAPPA-B TOLL-LIKE RECEPTOR-3 RIG-I MACROPHAGE RESPONSES CELL ACTIVATION IFN-BETA EXPRESSION MICE LIPOPROTEINS
英文摘要	LPS is the known component of bacterial pathogens that stimulates a number of proinflammatory factors. However, the mechanism of the induction of these factors by LPS has not been fully elucidated. We show here that LPS induces retinoic acid-inducible gene-I (RIG-I) in vitro and in vivo as a result from autocrine secretion of IFN-beta in macrophages. TIR-domain-containing adapter-inducing IFN-beta-deficient mouse embryo fibroblast (trif(-/-)) fail to show expression of RIG-I following LPS stimulation. Interference of RIG-I expression short interfering RNA represses the expression of LPS-induced TNF-alpha, whereas over-expression of RIG-I leads to the activation of TNF-alpha promoter and the induction of TNF-alpha expression. LPS- and IFN-beta-induced TNF-alpha are suppressed in RIG-I-deficient mouse embryo fibroblasts (rig(-/-)). Thus, RIG-I plays a key role in the expression of TNF-alpha in macropbages in response to LPS stimulation, mainly for the late phase LPS-induced expression of TNF-alpha.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000257404600025&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Immunology; SCI(E); 27; 12; 8011-8019; 180
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/397323]
专题	生命科学学院
推荐引用方式 GB/T 7714	Wang, Jing,Wu, Su,Jin, Xin,et al. Retinoic acid-inducible gene-I mediates late phase induction of TNF-alpha by lipopolysaccharide[J]. journal of immunology,2008.
APA	Wang, Jing.,Wu, Su.,Jin, Xin.,Li, Mingtao.,Chen, Shiyong.,...&Gu, Jun.(2008).Retinoic acid-inducible gene-I mediates late phase induction of TNF-alpha by lipopolysaccharide.journal of immunology.
MLA	Wang, Jing,et al."Retinoic acid-inducible gene-I mediates late phase induction of TNF-alpha by lipopolysaccharide".journal of immunology (2008).