Blue-light-dependent interaction of cryptochrome 1 with SPA1 defines a   dynamic signaling mechanism

doi:10.1101/gad.2025111

CORC > 北京大学 > 生命科学学院

	Blue-light-dependent interaction of cryptochrome 1 with SPA1 defines a dynamic signaling mechanism
	Lian, Hong-Li ; He, Sheng-Bo ; Zhang, Yan-Chun ; Zhu, Dan-Meng ; Zhang, Jing-Yi ; Jia, Kun-Peng ; Sun, Shu-Xia ; Li, Ling ; Yang, Hong-Quan
刊名	genes development
	2011
关键词	photoreceptor SPA1 COP1 cryptochrome 1 signaling COP1 E3 LIGASE ARABIDOPSIS CRYPTOCHROMES GENE-EXPRESSION REPEAT DOMAIN PHYTOCHROME PHOTOMORPHOGENESIS UBIQUITINATION PROTEINS HY5 TRANSDUCTION
DOI	10.1101/gad.2025111
英文摘要	Cryptochromes (CRYs) are blue-light photoreceptors that mediate various light responses in plants and animals. The signaling mechanism by which CRYs regulate light responses involves their physical interactions with COP1. Here, we report that CRY1 interacts physically with SPA1 in a blue-light-dependent manner. SPA acts genetically downstream from CRYs to regulate light-controlled development. Blue-light activation of CRY1 attenuates the association of COP1 with SPA1 in both yeast and plant cells. These results indicate that the blue-light-triggered CRY1-SPA1 interaction may negatively regulate COP1, at least in part, by promoting the dissociation of COP1 from SPA1. This interaction and consequent dissociation define a dynamic photosensory signaling mechanism.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000290611800004&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Cell Biology; Developmental Biology; Genetics & Heredity; SCI(E); 74; ARTICLE; 10; 1023-1028; 25
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/394771]
专题	生命科学学院
推荐引用方式 GB/T 7714	Lian, Hong-Li,He, Sheng-Bo,Zhang, Yan-Chun,et al. Blue-light-dependent interaction of cryptochrome 1 with SPA1 defines a dynamic signaling mechanism[J]. genes development,2011.
APA	Lian, Hong-Li.,He, Sheng-Bo.,Zhang, Yan-Chun.,Zhu, Dan-Meng.,Zhang, Jing-Yi.,...&Yang, Hong-Quan.(2011).Blue-light-dependent interaction of cryptochrome 1 with SPA1 defines a dynamic signaling mechanism.genes development.
MLA	Lian, Hong-Li,et al."Blue-light-dependent interaction of cryptochrome 1 with SPA1 defines a dynamic signaling mechanism".genes development (2011).