Galanin Protects Amyloid-beta-Induced Neurotoxicity on Primary Cultured   Hippocampal Neurons of Rats

doi:10.3233/JAD-2010-091234

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	Galanin Protects Amyloid-beta-Induced Neurotoxicity on Primary Cultured Hippocampal Neurons of Rats
	Cheng, Yong ; Yu, Long-Chuan
刊名	journal of alzheimers disease
	2010
关键词	Amyloid-beta Bax Bcl-2 caspase-3 Gal2-11 galanin galanin receptor 2 hippocampal neuron MAP2 Morris water maze neuroprotective effect p53 ALZHEIMERS-DISEASE A-BETA TAUROURSODEOXYCHOLIC ACID P53-MEDIATED APOPTOSIS PRECURSOR PROTEIN BAX TRANSLOCATION NUCLEUS BASALIS NERVOUS-SYSTEM CELL-DEATH PEPTIDE
DOI	10.3233/JAD-2010-091234
英文摘要	The neuropeptide galanin and its receptors are found to be upregulated in brain associated with Alzheimer's disease (AD), while the role of galanin in AD is still unclear. The present study was performed to explore the neuroprotective role of galanin both in vitro and in vivo. Our results demonstrated that galanin inhibited the neurotoxicity induced by amyloid-beta(25-35) (A beta(25-35)) or A beta(1-42) in primary cultured hippocampal neurons of rats. Moreover, Gal2-11 (an agonist of GalR2/3) also inhibited the neurotoxicity induced by A beta(25-35) in the cultured neurons. We further found that galanin inhibited the activation of p53, Bax, and caspase-3 induced by A beta(25-35) in the cultured hippocampal neurons. Moreover, galanin reversed the down regulation of Bcl-2 induced by A beta(25-35) in the cultured neurons. Interestingly, in the Morris water maze task we found that intra-CA1 injection of A beta(25-35)-induced spatial learning deficits in rats were blocked by galanin. In addition, galanin inhibited the A beta(25-35)-induced dysregulation of p53, Bax, and MAP2 in rat hippocampus. Our results strongly demonstrate that galanin plays neuroprotective roles in nerve cells and in AD-induced learning and memory deficits.; Neurosciences; SCI(E); PubMed; 13; ARTICLE; 4; 1143-1157; 20
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/344635]
专题	生命科学学院
推荐引用方式 GB/T 7714	Cheng, Yong,Yu, Long-Chuan. Galanin Protects Amyloid-beta-Induced Neurotoxicity on Primary Cultured Hippocampal Neurons of Rats[J]. journal of alzheimers disease,2010.
APA	Cheng, Yong,&Yu, Long-Chuan.(2010).Galanin Protects Amyloid-beta-Induced Neurotoxicity on Primary Cultured Hippocampal Neurons of Rats.journal of alzheimers disease.
MLA	Cheng, Yong,et al."Galanin Protects Amyloid-beta-Induced Neurotoxicity on Primary Cultured Hippocampal Neurons of Rats".journal of alzheimers disease (2010).