Retinoic acid inducible gene-I, more than a virus sensor

doi:10.1007/s13238-011-1045-y

CORC > 北京大学 > 生命科学学院

	Retinoic acid inducible gene-I, more than a virus sensor
	Liu, Feng ; Gu, Jun
刊名	protein cell
	2011
关键词	retinoic acid inducible gene-I (RIG-I) antiviral signaling inflammation innate immunity FIBROBLAST-LIKE SYNOVIOCYTES ANTIVIRAL IMMUNE-RESPONSES TUMOR-SUPPRESSOR CYLD DOUBLE-STRANDED-RNA HEPATITIS-C VIRUS INFLUENZA-A VIRUS HELICASE RIG-I NF-KAPPA-B INTERFERON-GAMMA UBIQUITIN LIGASE
DOI	10.1007/s13238-011-1045-y
英文摘要	Retinoic acid inducible gene-I (RIG-I) is a caspase recruitment domain (CARD) containing protein that acts as an intracellular RNA receptor and senses virus infection. After binding to double stranded RNA (dsRNA) or 5'-triphosphate single stranded RNA (ssRNA), RIG-I transforms into an open conformation, translocates onto mitochondria, and interacts with the downstream adaptor mitochondrial antiviral signaling (MAVS) to induce the production of type I interferon and inflammatory factors via IRF3/7 and NF-kappa B pathways, respectively. Recently, accumulating evidence suggests that RIG-I could function in non-viral systems and participate in a series of biological events, such as inflammation and inflammation related diseases, cell proliferation, apoptosis and even senescence. Here we review recent advances in antiviral study of RIG-I as well as the functions of RIG-I in other fields.; Cell Biology; SCI(E); PubMed; 中国科学引文数据库(CSCD); 22; REVIEW; 5; 351-357; 2
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/343712]
专题	生命科学学院
推荐引用方式 GB/T 7714	Liu, Feng,Gu, Jun. Retinoic acid inducible gene-I, more than a virus sensor[J]. protein cell,2011.
APA	Liu, Feng,&Gu, Jun.(2011).Retinoic acid inducible gene-I, more than a virus sensor.protein cell.
MLA	Liu, Feng,et al."Retinoic acid inducible gene-I, more than a virus sensor".protein cell (2011).