beta-Oxidation - strategies for the metabolism of a wide variety of   acyl-CoA esters

doi:10.1016/S1388-1981(00)00013-5

CORC > 北京大学 > 生命科学学院

	beta-Oxidation - strategies for the metabolism of a wide variety of acyl-CoA esters
	Hiltunen, JK ; Qin, YM
刊名	biochimica et biophysica acta molecular and cell biology of lipids
	2000
关键词	fatty acid mitochondrion peroxisome metabolic compartmentalization auxiliary enzyme paralogue UNSATURATED FATTY-ACIDS RAT-LIVER PEROXISOMES BIFUNCTIONAL PROTEIN-DEFICIENCY COENZYME-A DEHYDROGENASE SACCHAROMYCES-CEREVISIAE 3-HYDROXYACYL-COA DEHYDROGENASE 2,4-DIENOYL-COA REDUCTASE SHORT-CHAIN CRYSTAL-STRUCTURE ESCHERICHIA-COLI
DOI	10.1016/S1388-1981(00)00013-5
英文摘要	Living organisms are exposed to a number of different fatty acids and their various derivatives arising either via endogenous synthesis or from exogenous sources. These hydrophobic compounds can play specific metabolic, structural or endocrinic functions in the organisms before their elimination, which can be metabolism to CO(2) or to more polar lipid metabolites allowing their excretion. Quantitatively, one of the major pathways metabolizing fatty acids is beta-oxidation, which consists of a set of four reactions operating at the carbons 2 or 3 of acyl-CoA esters and shortening of the acyl-chain. To allow the beta-oxidation of acyl groups with various steric variants to proceed, different strategies have been developed. These strategies include evolution of beta-oxidation enzymes as paralogues showing specificity with respect to either chain-length or modified acyl-chain, metabolic compartmentalization in eukaryotic cells, controlling of substrate transport across membranes, development of auxiliary enzyme systems, acquisition of enzymes with adaptive active sites and recruiting and optimizing enzymes from non-homologous sources allowing them to catalyze a parallel set of reactions with different substrate specificities. (C) 2000 Elsevier Science B.V. All rights reserved.; Biochemistry & Molecular Biology; Biophysics; Cell Biology; SCI(E); 84; REVIEW; 2-3; 117-128; 1484
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/257765]
专题	生命科学学院
推荐引用方式 GB/T 7714	Hiltunen, JK,Qin, YM. beta-Oxidation - strategies for the metabolism of a wide variety of acyl-CoA esters[J]. biochimica et biophysica acta molecular and cell biology of lipids,2000.
APA	Hiltunen, JK,&Qin, YM.(2000).beta-Oxidation - strategies for the metabolism of a wide variety of acyl-CoA esters.biochimica et biophysica acta molecular and cell biology of lipids.
MLA	Hiltunen, JK,et al."beta-Oxidation - strategies for the metabolism of a wide variety of acyl-CoA esters".biochimica et biophysica acta molecular and cell biology of lipids (2000).