Advances in G-protein coupled receptor research and related   bioinformatics study

doi:10.1360/03tb9108

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	Advances in G-protein coupled receptor research and related bioinformatics study
	Yin, YB ; Luo, JC ; Jiang, J
刊名	科学通报英文版
	2003
关键词	GPCR signal transduction ligands orphan receptor bioinformatics RHODOPSIN DISCOVERY DATABASE IDENTIFICATION SEQUENCE FAMILY GPCRDB TOOL
DOI	10.1360/03tb9108
英文摘要	G-protein coupled receptor (GPCR) is one of the most important protein families for drug target. GPCR agonists and antagonists occupy approximately one third of the world small molecule drug market. Much effort has been invested in GPCR study by both academic institutions and pharmaceutical industries. With seven-transmembrane domains, GPCR plays significant roles in intercellular signal transduction and is involved in a variety of biological pathways. With the availability of sequence data of human and other mammalian genomes, as well as their expressed sequence tag (EST) data, the bioinformatics and genomics approaches can be applied to identifying novel GPCR in the post genomic era. Deorphanizing GPCR or matching ligands with GPCR greatly facilitates target validation process and automatically provides a possible compound screening assay. Similarly, bioinformatics data mining approach could also be applied to the identification of GPCR peptide or protein ligands. Here we give a general review of recent advances in the study of GPCR structure, function, as well as GPCR and ligand identification with the emphasis on the bioinformatics database mining of GPCR and their peptide or protein ligands.; Multidisciplinary Sciences; SCI(E); 1; REVIEW; 6; 511-516; 48
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/256053]
专题	生命科学学院
推荐引用方式 GB/T 7714	Yin, YB,Luo, JC,Jiang, J. Advances in G-protein coupled receptor research and related bioinformatics study[J]. 科学通报英文版,2003.
APA	Yin, YB,Luo, JC,&Jiang, J.(2003).Advances in G-protein coupled receptor research and related bioinformatics study.科学通报英文版.
MLA	Yin, YB,et al."Advances in G-protein coupled receptor research and related bioinformatics study".科学通报英文版 (2003).