Substance P microinjected into the periaqueductal gray matter induces   antinociception and is released following morphine administration

doi:10.1016/j.brainres.2003.11.060

CORC > 北京大学 > 生命科学学院

	Substance P microinjected into the periaqueductal gray matter induces antinociception and is released following morphine administration
	Rosen, A ; Zhang, YX ; Lund, I ; Lundeberg, T ; Yu, LC
刊名	脑研究
	2004
关键词	hindpaw withdrawal latency hot plate microdialysis periaqueductal gray substance P NK1 RECEPTOR ANTAGONISTS CENTRAL-NERVOUS-SYSTEM GENE-RELATED PEPTIDE RAT SPINAL-CORD ELECTRICAL-STIMULATION ANALGESIC ACTIVITY MOUSE-BRAIN TACHYKININS FRAGMENTS MIDBRAIN
DOI	10.1016/j.brainres.2003.11.060
英文摘要	The aims of the present study were to investigate, in rats, the behavioral effects of substance P (SP) microinjected into the ventrolateral periaqueductal gray (PAG) and the effects of the neurokinin I (NK-1) receptor antagonist [D-Arg1, D-Trp7, 9, Leu11]-substance P (Spantide). The effect of morphine administration on the release of SP in the ventrolateral PAG was also investigated using microdialysis in awake rats.SP microinjected into the ventrolateral part of the PAG induced significant increases in the hindpaw withdrawal latencies (HWLs) to thermal and mechanical stimulation as an antinociceptive response. The NK-1 receptor antagonist blocked these effects but exhibited no antinociceptive effect alone. Subcutaneous administration of morphine increased basal SP-like immuno reactivity (SP-LI) release in the microdialysate obtained from the ventrolateral PAG of freely moving rats. Our results demonstrate that SP injected into the ventrolateral PAG induces an antinociceptive effect via activation of NK-1 receptors. Morphine administered systemically induces the release of SP in the ventrolateral PAG. We suggest that an increased release of SP in the PAG may contribute to opioid antinociception. (C) 2004 Elsevier B.V. All rights reserved.; Neurosciences; SCI(E); 32; ARTICLE; 1-2; 87-94; 1001
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/255400]
专题	生命科学学院
推荐引用方式 GB/T 7714	Rosen, A,Zhang, YX,Lund, I,et al. Substance P microinjected into the periaqueductal gray matter induces antinociception and is released following morphine administration[J]. 脑研究,2004.
APA	Rosen, A,Zhang, YX,Lund, I,Lundeberg, T,&Yu, LC.(2004).Substance P microinjected into the periaqueductal gray matter induces antinociception and is released following morphine administration.脑研究.
MLA	Rosen, A,et al."Substance P microinjected into the periaqueductal gray matter induces antinociception and is released following morphine administration".脑研究 (2004).