Coexpression Networks Implicate Human Midfetal Deep Cortical Projection   Neurons in the Pathogenesis of Autism

doi:10.1016/j.cell.2013.10.020

CORC > 北京大学 > 生命科学学院

	Coexpression Networks Implicate Human Midfetal Deep Cortical Projection Neurons in the Pathogenesis of Autism
	Willsey, A. Jeremy ; Sanders, Stephan J. ; Li, Mingfeng ; Dong, Shan ; Tebbenkamp, Andrew T. ; Muhle, Rebecca A. ; Reilly, Steven K. ; Lin, Leon ; Fertuzinhos, Sofia ; Miller, Jeremy A. ; Murtha, Michael T. ; Bichsel, Candace ; Niu, Wei ; Cotney, Justin ; Ercan-Sencicek, A. Gulhan ; Gockley, Jake ; Gupta, Abha R. ; Han, Wenqi ; He, Xin ; Hoffman, Ellen J. ; Klei, Lambertus ; Lei, Jing ; Liu, Wenzhong ; Liu, Li ; Lu, Cong ; Xu, Xuming ; Zhu, Ying ; Mane, Shrikant M. ; Lein, Ed S. ; Wei, Liping ; Noonan, James P. ; Roeder, Kathryn ; Devlin, Bernie ; Sestan, Nenad ; State, Mat
刊名	cell
	2013
关键词	SPECTRUM DISORDERS NOVO MUTATIONS GENES RISK CNVS
DOI	10.1016/j.cell.2013.10.020
英文摘要	Autism spectrum disorder (ASD) is a complex developmental syndrome of unknown etiology. Recent studies employing exome- and genome-wide sequencing have identified nine high-confidence ASD (hcASD) genes. Working from the hypothesis that ASD-associated mutations in these biologically pleiotropic genes will disrupt intersecting developmental processes to contribute to a common phenotype, we have attempted to identify time periods, brain regions, and cell types in which these genes converge. We have constructed coexpression networks based on the hcASD "seed'' genes, leveraging a rich expression data set encompassing multiple human brain regions across human development and into adulthood. By assessing enrichment of an independent set of probable ASD (pASD) genes, derived from the same sequencing studies, we demonstrate a key point of convergence in midfetal layer 5/6 cortical projection neurons. This approach informs when, where, and in what cell types mutations in these specific genes may be productively studied to clarify ASD pathophysiology.; Biochemistry & Molecular Biology; Cell Biology; SCI(E); 77; ARTICLE; 5; 997-1007; 155
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/219832]
专题	生命科学学院
推荐引用方式 GB/T 7714	Willsey, A. Jeremy,Sanders, Stephan J.,Li, Mingfeng,et al. Coexpression Networks Implicate Human Midfetal Deep Cortical Projection Neurons in the Pathogenesis of Autism[J]. cell,2013.
APA	Willsey, A. Jeremy.,Sanders, Stephan J..,Li, Mingfeng.,Dong, Shan.,Tebbenkamp, Andrew T..,...&State, Mat.(2013).Coexpression Networks Implicate Human Midfetal Deep Cortical Projection Neurons in the Pathogenesis of Autism.cell.
MLA	Willsey, A. Jeremy,et al."Coexpression Networks Implicate Human Midfetal Deep Cortical Projection Neurons in the Pathogenesis of Autism".cell (2013).