Bcl-2 Antagonists Kill Plasmacytoid Dendritic Cells From Lupus-Prone   Mice and Dampen Interferon-alpha Production

doi:10.1002/art.38966

CORC > 北京大学 > 生命科学学院

	Bcl-2 Antagonists Kill Plasmacytoid Dendritic Cells From Lupus-Prone Mice and Dampen Interferon-alpha Production
	Zhan, Yifan ; Carrington, Emma M. ; Ko, Hyun-Ja ; Vikstrom, Ingela B. ; Oon, Shereen ; Zhang, Jian-Guo ; Vremec, David ; Brady, Jamie L. ; Bouillet, Philippe ; Wu, Li ; Huang, David C. S. ; Wicks, Ian P. ; Morand, Eric F. ; Strasser, Andreas ; Lew, Andrew M.
刊名	arthritis rheumatology
	2015
关键词	AUTOIMMUNE-DISEASE NUCLEIC-ACIDS BH3 MIMETICS TH17 CELLS IFN-ALPHA T-CELL ERYTHEMATOSUS PATHOGENESIS EXPRESSION PROTEINS
DOI	10.1002/art.38966
英文摘要	Objective. Interferon- (IFN alpha)-producing plasmacytoid dendritic cells (PDCs) are implicated in the pathogenesis of systemic lupus erythematosus (SLE). IFN-related genes are highlighted among SLE susceptibility alleles and are characteristically expressed in the blood of patients with SLE, while in mouse models of lupus, PDC numbers and IFN production are increased. This study was undertaken to investigate the effects of inhibitors that selectively target different antiapoptotic molecules on the survival of PDCs. Methods. PDC numbers, in vitro survival, and expression of antiapoptotic molecules were evaluated in lupus-prone (NZB x NZW)F1 (NZB/NZW) mice. The impact of Bcl-2 antagonists and glucocorticoids on PDCs was evaluated in vitro and in vivo. IFN production by NZB/NZW mice was evaluated before and after treatment with Bcl-2 antagonists. Results. PDCs, but not lymphoid tissue-resident conventional DCs, largely relied on the antiapoptotic protein Bcl-2 for survival. The enlarged PDC compartment in NZB/NZW mice was associated with selectively prolonged survival and increased Bcl-2 transcription. Functionally, this resulted in enhanced production of IFN. Bcl-2 inhibitors selectively killed mouse and human PDCs, including PDCs from SLE patients, but not conventional DCs, dampened IFN production by PDCs, and synergized with glucocorticoids to kill activated PDCs. Conclusion. Enhanced PDC survival is a likely contributing factor to enhanced IFN production by lupus PDCs. Bcl-2 antagonists potently and selectively kill PDCs and reduce IFN alpha production. Thus, we believe that they are attractive candidates for treating PDC-associated diseases.; Rheumatology; SCI(E); 0; ARTICLE; zhan@wehi.edu.au; 3; 797-808; 67
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/206104]
专题	生命科学学院
推荐引用方式 GB/T 7714	Zhan, Yifan,Carrington, Emma M.,Ko, Hyun-Ja,et al. Bcl-2 Antagonists Kill Plasmacytoid Dendritic Cells From Lupus-Prone Mice and Dampen Interferon-alpha Production[J]. arthritis rheumatology,2015.
APA	Zhan, Yifan.,Carrington, Emma M..,Ko, Hyun-Ja.,Vikstrom, Ingela B..,Oon, Shereen.,...&Lew, Andrew M..(2015).Bcl-2 Antagonists Kill Plasmacytoid Dendritic Cells From Lupus-Prone Mice and Dampen Interferon-alpha Production.arthritis rheumatology.
MLA	Zhan, Yifan,et al."Bcl-2 Antagonists Kill Plasmacytoid Dendritic Cells From Lupus-Prone Mice and Dampen Interferon-alpha Production".arthritis rheumatology (2015).