Involvement of opioid receptors in the oxytocin-induced antinociception   in the central nervous system of rats

doi:10.1016/j.regpep.2004.02.011

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	Involvement of opioid receptors in the oxytocin-induced antinociception in the central nervous system of rats
	Gao, L ; Yu, LC
刊名	正规肽
	2004
关键词	antinociception oxytocin mu-opioid receptor kappa-opioid receptor hindpaw withdrawal latency intracerebroventricular injection SPINAL ANTINOCICEPTION ANTI-NOCICEPTION VASOPRESSIN ANALGESIA MICE PAIN MONONEUROPATHY INFLAMMATION ANTAGONISTS SELECTIVITY
DOI	10.1016/j.regpep.2004.02.011
英文摘要	Recent studies showed that oxytocin and opioid peptides play important roles in pain modulation at different levels in the central nervous system. The present study was performed to explore whether opioid system is involved in the oxytocin-induced antinociception in the brain of rats. The results showed that: (1) intracerebroventricular injection of oxytocin induced dose-dependent increases in hindpaw withdrawal latencies (HWL) to noxious thermal and mechanical stimulation in rats. (2) The antinociceptive effect of oxytocin was attenuated dose-dependently by intracerebroventricular injection of naloxone, indicating an involvement of opioid system in the oxytocin-induced antinociception. (3) It is interesting that the antinociceptive effect of oxytocin was attenuated by subsequent intracerebroventricular injection of the mu-opioid antagonist beta-funaltrexamine (beta-FNA) and the kappa-opioid antagonist nor-binaltorphimine (nor-BNI), but not the delta-opioid antagonist naltrindole. The results indicate that oxytocin plays an antinociceptive role in the brain of rats; mu- and kappa-opioid receptors, not delta-receptors, are involved in the oxytocin-induced antinociception in the central nervous system of rats. (C) 2004 Elsevier B.V. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000222225600007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Endocrinology & Metabolism; Physiology; SCI(E); PubMed; 33; ARTICLE; 1-3; 53-58; 120
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/199563]
专题	生命科学学院
推荐引用方式 GB/T 7714	Gao, L,Yu, LC. Involvement of opioid receptors in the oxytocin-induced antinociception in the central nervous system of rats[J]. 正规肽,2004.
APA	Gao, L,&Yu, LC.(2004).Involvement of opioid receptors in the oxytocin-induced antinociception in the central nervous system of rats.正规肽.
MLA	Gao, L,et al."Involvement of opioid receptors in the oxytocin-induced antinociception in the central nervous system of rats".正规肽 (2004).