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	Ischemia activates JNK/c-Jun/AP-1 pathway to up-regulate 14-3-3 gamma in astrocyte
	Dong, Yan ; Liu, Hua Dong ; Zhao, Rui ; Yang, Chun Zhang ; Chen, Xiao Qian ; Wang, Xin Hong ; Lau, Lok Ting ; Chen, Jianguo ; Yu, Albert Cheung Hoi
	2009
关键词	AP-1 astrocytes c-Jun JNK ischemia 14-3-3 gamma CEREBRAL-ISCHEMIA INDUCED APOPTOSIS PRIMARY CULTURES GENE-EXPRESSION PROTEIN-KINASE INJURY CELLS INDUCTION TOLERANCE BRAIN
英文摘要	Ischemia occurs in the brain as the result of stroke and other related injuries and few therapies are effective. If more is understood then potential treatments could be investigated. It was previously reported that 14-3-3 gamma could be up-regulated by ischemia in astrocyte to protect cells from ischemia-induced apoptosis. In this study, we attempted to uncover the mechanism responsible for this 14-3-3 gamma up-regulation in primary culture of astrocytes under ischemic-like conditions. It was found that in vitro ischemia may activate PI3K/Akt and MAPK signaling pathways. Astrocyte cultures were treated with LY294002 (PI3K inhibitor), U0126 (ERK inhibitor), SB203580 (p38 inhibitor) and SP600125 (JNK inhibitor). Only SP600125 could inhibit the ischemia-induced 14-3-3 gamma up-regulation in astrocytes. At the same time, we observed an ischemia-induced nuclear translocation of p-c-Jun, a major downstream component of JNK. Inhibition of AP-1 with curcumin also inhibited 14-3-3 gamma up-regulation indicating that ischemia-induced up-regulation of 14-3-3 gamma in astrocyte involves activation of the JNK/p-c-Jun/AP-1 pathway.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000265013900026&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Biochemistry & Molecular Biology; Neurosciences; SCI(E); CPCI-S(ISTP); PubMed; 20
语种	英语
DOI标识	10.1111/j.1471-4159.2009.05974.x
内容类型	其他
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/197604]
专题	生命科学学院
推荐引用方式 GB/T 7714	Dong, Yan,Liu, Hua Dong,Zhao, Rui,et al. Ischemia activates JNK/c-Jun/AP-1 pathway to up-regulate 14-3-3 gamma in astrocyte. 2009-01-01.

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