Antinociceptive effects induced by intra-periaqueductal grey injection   of the galanin receptor 1 agonist M617 in rats with morphine tolerance

doi:10.1016/j.neulet.2013.06.059

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	Antinociceptive effects induced by intra-periaqueductal grey injection of the galanin receptor 1 agonist M617 in rats with morphine tolerance
	Kong, Qingyao ; Yu, Long-Chuan
刊名	神经科学快报
	2013
关键词	Antinociceptive effect Galanin Galanin receptor 1 Hindpaw withdrawal latency Periaqueductal grey Morphine tolerance CENTRAL-NERVOUS-SYSTEM OPIOID RECEPTORS CENTRAL NUCLEUS INVOLVEMENT NOCICEPTION AMYGDALA GRAY PAIN
DOI	10.1016/j.neulet.2013.06.059
英文摘要	The present study was performed to investigate the antinociceptive effects of M617, a selective galanin receptor 1 agonist, and M1145, a selective galanin receptor 2 agonist, in the periaqueductal grey (PAG) in rats with morphine tolerance. Intra-PAG injection of 0.1 nmol, 0.5 nmol and 1 nmol of M617 induced dose-dependent increases in hindpaw withdrawal latencies (HWLs) to noxious thermal and mechanical stimulations in rats with morphine tolerance. Nevertheless, intra-PAG injection of 5 nmol of the selective galanin receptor 2 agonist M1145 showed no significant influences on HWLs to noxious thermal and mechanical stimulations in rats with morphine tolerance. The results demonstrated that it is the selective galanin receptor 1 agonist M617, not the selective galanin receptor 2 agonist M1145, induced significant antinociceptive effects in morphine-tolerant rats, indicating that galanin receptor I is involved in nociceptive modulation in the PAG of morphine-tolerant rats. (C) 2013 Elsevier Ireland Ltd. All rights reserved.; Neurosciences; SCI(E); PubMed; 2; ARTICLE; 125-128; 550
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/190476]
专题	生命科学学院
推荐引用方式 GB/T 7714	Kong, Qingyao,Yu, Long-Chuan. Antinociceptive effects induced by intra-periaqueductal grey injection of the galanin receptor 1 agonist M617 in rats with morphine tolerance[J]. 神经科学快报,2013.
APA	Kong, Qingyao,&Yu, Long-Chuan.(2013).Antinociceptive effects induced by intra-periaqueductal grey injection of the galanin receptor 1 agonist M617 in rats with morphine tolerance.神经科学快报.
MLA	Kong, Qingyao,et al."Antinociceptive effects induced by intra-periaqueductal grey injection of the galanin receptor 1 agonist M617 in rats with morphine tolerance".神经科学快报 (2013).