An Unconditioned Stimulus Retrieval Extinction Procedure to Prevent the   Return of Fear Memory

doi:10.1016/j.biopsych.2014.03.027

CORC > 北京大学 > 生命科学学院

	An Unconditioned Stimulus Retrieval Extinction Procedure to Prevent the Return of Fear Memory
	Liu, Jianfeng ; Zhao, Liyan ; Xue, Yanxue ; Shi, Jie ; Suo, Lin ; Luo, Yixiao ; Chai, Baisheng ; Yang, Chang ; Fang, Qin ; Zhang, Yan ; Bao, Yanping ; Pickens, Charles L. ; Lu, Lin
刊名	生物精神病学
	2014
关键词	Extinction fear memory hippocampus reconsolidation retrieval unconditioned stimulus POSTTRAUMATIC-STRESS-DISORDER CONDITIONED FEAR CONTEXTUAL FEAR EXPOSURE THERAPY D-CYCLOSERINE RECONSOLIDATION AMYGDALA CONSOLIDATION RELAPSE HUMANS
DOI	10.1016/j.biopsych.2014.03.027
英文摘要	Background: Conditioned fear memories can be updated by extinction during reconsolidation, and this effect is specific to the reactivated conditioned stimulus (CS). However, a traumatic event can be associated with several cues, and each cue can potentially trigger recollection of the event. We introduced a technique to target all diverse cues associated with an aversive event that causes fear. Methods: In human experiments, 161 subjects underwent modified fear conditioning, in which they were exposed to an unconditioned stimulus (US) or unreinforced CS to reactivate the memory and then underwent extinction, spontaneous recovery, and reinstatement. In animal experiments, 343 rats underwent contextual fear conditioning under a similar protocol as that used in the human experiments. We also explored the molecular alterations after US reactivation in rats. Results: Presentation of a lower intensity US before extinction disrupted the associations between the different CS and reactivated US in both humans and rats. This effect persisted for at least 6 months in humans and was selective to the reactivated US. This procedure was also effective for remote memories in both humans and rats. Compared with the CS, the US induced stronger endocytosis of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid glutamate receptors 1 and 2 and stronger activation of protein kinase A, p70S6 kinase, and cyclic adenosine monophosphate response element binding protein in the dorsal hippocampus in rats. Conclusions: These findings demonstrate that a modified US retrieval extinction strategy may have a potential impact on therapeutic approaches to prevent the return of fear.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000344733200012&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Neurosciences; Psychiatry; SCI(E); PubMed; SSCI; 9; ARTICLE; linlu@bjmu.edu.cn; 11; 895-901; 76
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/189686]
专题	生命科学学院
推荐引用方式 GB/T 7714	Liu, Jianfeng,Zhao, Liyan,Xue, Yanxue,et al. An Unconditioned Stimulus Retrieval Extinction Procedure to Prevent the Return of Fear Memory[J]. 生物精神病学,2014.
APA	Liu, Jianfeng.,Zhao, Liyan.,Xue, Yanxue.,Shi, Jie.,Suo, Lin.,...&Lu, Lin.(2014).An Unconditioned Stimulus Retrieval Extinction Procedure to Prevent the Return of Fear Memory.生物精神病学.
MLA	Liu, Jianfeng,et al."An Unconditioned Stimulus Retrieval Extinction Procedure to Prevent the Return of Fear Memory".生物精神病学 (2014).