The FLS2-Associated Kinase BIK1 Directly Phosphorylates the NADPH   Oxidase RbohD to Control Plant Immunity

doi:10.1016/j.chom.2014.02.009

CORC > 北京大学 > 生命科学学院

	The FLS2-Associated Kinase BIK1 Directly Phosphorylates the NADPH Oxidase RbohD to Control Plant Immunity
	Li, Lei ; Li, Meng ; Yu, Liping ; Zhou, Zhaoyang ; Liang, Xiangxiu ; Liu, Zixu ; Cai, Gaihong ; Gao, Liyan ; Zhang, Xiaojuan ; Wang, Yingchun ; Chen, She ; Zhou, Jian-Min
刊名	cell host microbe
	2014
关键词	PSEUDOMONAS-SYRINGAE EFFECTOR PLASMA-MEMBRANE PROTEIN-KINASES INNATE IMMUNITY ARABIDOPSIS-THALIANA MOLECULAR-PATTERNS DEFENSE RESPONSES RECEPTOR KINASE PERCEPTION ACTIVATION
DOI	10.1016/j.chom.2014.02.009
英文摘要	The Arabidopsis immune receptor FLS2 senses the bacterial flagellin epitope flg22 to activate transient elevation of cytosolic calcium ions, production of reactive oxygen species (ROS), and other signaling events to coordinate antimicrobial defenses, such as stomatal closure that limits bacterial invasion. However, how FLS2 regulates these signaling events remains largely unknown. Here we show that the receptor- like cytoplasmic kinase BIK1, a component of the FLS2 immune receptor complex, not only positively regulates flg22-triggered calcium influx but also directly phosphorylates the NADPH oxidase RbohD at specific sites in a calcium- independent manner to enhance ROS generation. Furthermore, BIK1 and RbohD form a pathway that controls stomatal movement in response to flg22, thereby restricting bacterial entry into leaf tissues. These findings highlight a direct role of the FLS2 complex in the regulation of RbohD- mediated ROS production and stomatal defense.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000333098600011&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Microbiology; Parasitology; Virology; SCI(E); PubMed; 57; ARTICLE; jmzhou@genetics.ac.cn; 3; 329-338; 15
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/189371]
专题	生命科学学院
推荐引用方式 GB/T 7714	Li, Lei,Li, Meng,Yu, Liping,et al. The FLS2-Associated Kinase BIK1 Directly Phosphorylates the NADPH Oxidase RbohD to Control Plant Immunity[J]. cell host microbe,2014.
APA	Li, Lei.,Li, Meng.,Yu, Liping.,Zhou, Zhaoyang.,Liang, Xiangxiu.,...&Zhou, Jian-Min.(2014).The FLS2-Associated Kinase BIK1 Directly Phosphorylates the NADPH Oxidase RbohD to Control Plant Immunity.cell host microbe.
MLA	Li, Lei,et al."The FLS2-Associated Kinase BIK1 Directly Phosphorylates the NADPH Oxidase RbohD to Control Plant Immunity".cell host microbe (2014).