HSCARG downregulates NF-kappa B signaling by interacting with USP7 and   inhibiting NEMO ubiquitination

doi:10.1038/cddis.2014.197

CORC > 北京大学 > 生命科学学院

	HSCARG downregulates NF-kappa B signaling by interacting with USP7 and inhibiting NEMO ubiquitination
	Li, T. ; Guan, J. ; Li, S. ; Zhang, X. ; Zheng, X.
刊名	cell death disease
	2014
关键词	HSCARG NF-kappa B USP7 NEMO ubiquitination KINASE IKK POLYUBIQUITIN BINDING ACTIVATION ALPHA PATHWAY COMPLEX PROTEIN SITE TNF TRANSCRIPTION
DOI	10.1038/cddis.2014.197
英文摘要	Nuclear factor kappa B (NF-kappa B) signaling is a central pathway that participates in a variety of key processes, including immunity, inflammation, cell growth and differentiation. The activity of NF-kappa B is strictly regulated by a cluster of proteins, and modifications of these proteins either promote or suppress signal transduction at various steps. Here we demonstrated that HSCARG suppresses TNF alpha-stimulated NF-kappa B signaling under physiological conditions. We elucidated the detailed mechanism through which HSCARG inhibits NF-kappa B activation. HSCARG interacts with NEMO and suppresses polyubiquitination of NEMO by interacting with the deubiquitinase USP7. HSACRG attenuates its inhibitory effect on NEMO ubiquitination in USP7 knockdown cells, and inhibition of NEMO polyubiquitination by USP7 is impaired in HSCARG(-/-) cells as well. Moreover, we demonstrated that USP7 is a negative regulator of TNF alpha-stimulated NF-kappa B activity. Altogether, our data indicate that HSCARG and USP7 function in concert in inhibiting polyubiquination of NEMO, thus inhibiting NF-kappa B activity.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000337229300029&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Cell Biology; SCI(E); PubMed; 0; ARTICLE; xiaofengz@pku.edu.cn; ,SI; e1229; 5
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/189061]
专题	生命科学学院
推荐引用方式 GB/T 7714	Li, T.,Guan, J.,Li, S.,et al. HSCARG downregulates NF-kappa B signaling by interacting with USP7 and inhibiting NEMO ubiquitination[J]. cell death disease,2014.
APA	Li, T.,Guan, J.,Li, S.,Zhang, X.,&Zheng, X..(2014).HSCARG downregulates NF-kappa B signaling by interacting with USP7 and inhibiting NEMO ubiquitination.cell death disease.
MLA	Li, T.,et al."HSCARG downregulates NF-kappa B signaling by interacting with USP7 and inhibiting NEMO ubiquitination".cell death disease (2014).