Generic Properties of Random Gene Regulatory Networks

doi:10.1007/s40484-014-0026-6

CORC > 北京大学 > 生命科学学院

	Generic Properties of Random Gene Regulatory Networks
	Li Zhiyuan ; Bianco Simone ; Zhang Zhaoyang ; Tang Chao
刊名	quantitative biology
	2013
关键词	Genetic network,complex systems,dynamic attractors
DOI	10.1007/s40484-014-0026-6
英文摘要	Modeling gene regulatory networks (GRNs) is an important topic in systems biology. Although there has been much work focusing on various specific systems, the generic behavior of GRNs with continuous variables is still elusive. In particular, it is not clear typically how attractors partition among the three types of orbits: steady state, periodic and chaotic, and how the dynamical properties change with network's topological characteristics. In this work, we first investigated these questions in random GRNs with different network sizes, connectivity, fraction of inhibitory links and transcription regulation rules. Then we searched for the core motifs that govern the dynamic behavior of large GRNs. We show that the stability of a random GRN is typically governed by a few embedding motifs of small sizes, and therefore can in general be understood in the context of these short motifs. Our results provide insights for the study and design of genetic networks.; PubMed; 0; 4; 253-260; 1
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/188893]
专题	生命科学学院
推荐引用方式 GB/T 7714	Li Zhiyuan,Bianco Simone,Zhang Zhaoyang,et al. Generic Properties of Random Gene Regulatory Networks[J]. quantitative biology,2013.
APA	Li Zhiyuan,Bianco Simone,Zhang Zhaoyang,&Tang Chao.(2013).Generic Properties of Random Gene Regulatory Networks.quantitative biology.
MLA	Li Zhiyuan,et al."Generic Properties of Random Gene Regulatory Networks".quantitative biology (2013).