The hippocampal proteomic analysis of senescence-accelerated mouse:   Implications of Uchl3 and mitofilin in cognitive disorder and   mitochondria dysfunction in SAMP8

doi:10.1007/s11064-008-9628-6

CORC > 北京大学 > 生命科学学院

	The hippocampal proteomic analysis of senescence-accelerated mouse: Implications of Uchl3 and mitofilin in cognitive disorder and mitochondria dysfunction in SAMP8
	Wang, Qingsong ; Liu, Yashu ; Zou, Xiao ; Wang, Qian ; An, Mingrui ; Guan, Xin ; He, Jintang ; Tong, Yuanpeng ; Ji, Jianguo
刊名	神经化学研究
	2008
关键词	hippocampus mitofilin proteomics senescence-accelerated mouse Uchl3 2-DE C-TERMINAL HYDROLASES AGE-RELATED-CHANGES OXIDATIVE STRESS GENE-EXPRESSION ALZHEIMERS-DISEASE ANIMAL-MODEL MICE BRAIN PROTEIN MEMORY
DOI	10.1007/s11064-008-9628-6
英文摘要	Senescence-accelerated mouse prone 8 (SAMP8) is considered as a useful animal model for age-related learning and memory impairments. Hippocampus, a critical brain region associated with cognitive decline during normal aging and various neurodegenerative diseases, appeared a series of abnormalities in SAMP8. To investigate the molecular mechanisms underlying age-related cognitive disorders, we used 2-DE coupled with MALDI TOF/TOF MS to analyze the differential protein expression of the hippocampus of SAMP8 at 6-month-old compared with the age-matched SAM/resistant 1 (SAMR1) which shows normal aging process. Two proteins were found to be markedly changed in SAMP8 as compared to SAMR1: ubiquitin carboxyl-terminal hydrolase L3 (Uchl3), implicating in cytosolic proteolysis of oxidatively damaged proteins, was down-regulated while mitofilin, a vital protein for normal mitochondria function, exhibited four isoforms with a consistent basic shift of isoelectric point among the soluble hippocampal proteins in SAMP8 compared with SAMR1. The alterations were confirmed by Western blotting analysis. The analysis of their expression changes may shed light on the mechanisms of learning and memory deficits and mitochondrial dysfunction as observed in SAMP8.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000258064900014&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Biochemistry & Molecular Biology; Neurosciences; SCI(E); PubMed; 16; ARTICLE; 9; 1776-1782; 33
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/162633]
专题	生命科学学院
推荐引用方式 GB/T 7714	Wang, Qingsong,Liu, Yashu,Zou, Xiao,et al. The hippocampal proteomic analysis of senescence-accelerated mouse: Implications of Uchl3 and mitofilin in cognitive disorder and mitochondria dysfunction in SAMP8[J]. 神经化学研究,2008.
APA	Wang, Qingsong.,Liu, Yashu.,Zou, Xiao.,Wang, Qian.,An, Mingrui.,...&Ji, Jianguo.(2008).The hippocampal proteomic analysis of senescence-accelerated mouse: Implications of Uchl3 and mitofilin in cognitive disorder and mitochondria dysfunction in SAMP8.神经化学研究.
MLA	Wang, Qingsong,et al."The hippocampal proteomic analysis of senescence-accelerated mouse: Implications of Uchl3 and mitofilin in cognitive disorder and mitochondria dysfunction in SAMP8".神经化学研究 (2008).