LRRC45 Is a Centrosome Linker Component Required for Centrosome Cohesion

doi:10.1016/j.celrep.2013.08.005

CORC > 北京大学 > 生命科学学院

	LRRC45 Is a Centrosome Linker Component Required for Centrosome Cohesion
	He, Runsheng ; Huang, Ning ; Bao, Yitian ; Zhou, Haining ; Teng, Junlin ; Chen, Jianguo
刊名	cell reports
	2013
关键词	COILED-COIL PROTEIN KINASE NEK2 C-NAP1 BIOGENESIS ROOTLETIN DUPLICATION MECHANISMS SEPARATION BIOLOGY SMC
DOI	10.1016/j.celrep.2013.08.005
英文摘要	During interphase, centrosomes are connected by a proteinaceous linker between the proximal ends of the centrioles, which is important for the centrosomes to function as a single microtubule-organizing center. However, the composition and regulation of centrosomal linker remain largely unknown. Here, we show that LRRC45 is a centrosome linker that localizes at the proximal ends of the centrioles and forms fiber-like structures between them. Depletion of LRRC45 results in centrosome splitting during interphase. Moreover, LRRC45 interacts with both C-Nap1 and rootletin and is phosphorylated by Nek2A at S661 during mitosis. After phosphorylation, both LRRC45 centrosomal localization and fiber-like structures are significantly reduced, which subsequently leads to centrosome separation. Thus, LRRC45 is a critical component of the proteinaceous linker between two centrioles and is required for centrosome cohesion.; Cell Biology; SCI(E); PubMed; 10; ARTICLE; 6; 1100-1107; 4
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/162472]
专题	生命科学学院
推荐引用方式 GB/T 7714	He, Runsheng,Huang, Ning,Bao, Yitian,et al. LRRC45 Is a Centrosome Linker Component Required for Centrosome Cohesion[J]. cell reports,2013.
APA	He, Runsheng,Huang, Ning,Bao, Yitian,Zhou, Haining,Teng, Junlin,&Chen, Jianguo.(2013).LRRC45 Is a Centrosome Linker Component Required for Centrosome Cohesion.cell reports.
MLA	He, Runsheng,et al."LRRC45 Is a Centrosome Linker Component Required for Centrosome Cohesion".cell reports (2013).