Arginine Methylation Modulates Autophagic Degradation of PGL Granules in   C. elegans

doi:10.1016/j.molcel.2013.09.014

CORC > 北京大学 > 生命科学学院

	Arginine Methylation Modulates Autophagic Degradation of PGL Granules in C. elegans
	Li, Sihui ; Yang, Peiguo ; Tian, E. ; Zhang, Hong
刊名	分子细胞
	2013
关键词	SELECTIVE AUTOPHAGY LINKS CARGO PROTEIN PHOSPHORYLATION MITOPHAGY ATG11 YEAST ATG32 MECHANISMS HUNTINGTIN
DOI	10.1016/j.molcel.2013.09.014
英文摘要	The selective degradation of intracellular components by autophagy involves sequential interactions of the cargo with a receptor, which also binds the autophagosonnal protein Atg8 and a scaffold protein. Here, we demonstrated that mutations in C. elegans epg-11, which encodes an arginine methyltransferase homologous to PRMT1, cause the defective removal of PGL-1 and PGL-3 (cargo)-SEPA-1 (receptor) complexes, known as PGL granules, from somatic cells during embryogenesis. Autophagic degradation of the PGL granule scaffold protein EPG-2 and other protein aggregates was unaffected in epg-11/prmt-1 mutants. Loss of epg-11/prmt-1 activity impairs the association of PGL granules with EPG-2 and LGG-1 puncta. EPG-11/PRMT-1 directly methylates arginines in the RGG domains of PGL-1 and PGL-3. Autophagic removal of PGL proteins is impaired when the methylated arginines are mutated. Our study reveals that posttranslational arginine methylation regulates the association of the cargo-receptor complex with the scaffold protein, providing a mechanism for modulating degradation efficiency in selective autophagy.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000326852500013&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Biochemistry & Molecular Biology; Cell Biology; SCI(E); PubMed; 13; ARTICLE; 3; 421-433; 52
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/162467]
专题	生命科学学院
推荐引用方式 GB/T 7714	Li, Sihui,Yang, Peiguo,Tian, E.,et al. Arginine Methylation Modulates Autophagic Degradation of PGL Granules in C. elegans[J]. 分子细胞,2013.
APA	Li, Sihui,Yang, Peiguo,Tian, E.,&Zhang, Hong.(2013).Arginine Methylation Modulates Autophagic Degradation of PGL Granules in C. elegans.分子细胞.
MLA	Li, Sihui,et al."Arginine Methylation Modulates Autophagic Degradation of PGL Granules in C. elegans".分子细胞 (2013).