EDdb: A web resource for eating disorder and its application to identify   an extended adipocytokine signaling pathway related to eating disorder

doi:10.1007/s11427-013-4573-2

CORC > 北京大学 > 生命科学学院

	EDdb: A web resource for eating disorder and its application to identify an extended adipocytokine signaling pathway related to eating disorder
	Zhao Min ; Li XiaoMo ; Qu Hong
刊名	science china life sciences
	2013
关键词	eating disorder database adipocytokine signaling pathway pathway analysis COMORBIDITY-SURVEY-REPLICATION RATE-LIMITING ENZYMES ANOREXIA-NERVOSA GENE POLYMORPHISMS INSULIN-RESISTANCE METABOLIC PATHWAYS PROSTATE-CANCER SKELETAL-MUSCLE BULIMIA-NERVOSA PKC-THETA
DOI	10.1007/s11427-013-4573-2
英文摘要	Eating disorder is a group of physiological and psychological disorders affecting approximately 1% of the female population worldwide. Although the genetic epidemiology of eating disorder is becoming increasingly clear with accumulated studies, the underlying molecular mechanisms are still unclear. Recently, integration of various high-throughput data expanded the range of candidate genes and started to generate hypotheses for understanding potential pathogenesis in complex diseases. This article presents EDdb (Eating Disorder database), the first evidence-based gene resource for eating disorder. Fifty-nine experimentally validated genes from the literature in relation to eating disorder were collected as the core dataset. Another four datasets with 2824 candidate genes across 601 genome regions were expanded based on the core dataset using different criteria (e.g., protein-protein interactions, shared cytobands, and related complex diseases). Based on human protein-protein interaction data, we reconstructed a potential molecular sub-network related to eating disorder. Furthermore, with an integrative pathway enrichment analysis of genes in EDdb, we identified an extended adipocytokine signaling pathway in eating disorder. Three genes in EDdb (ADIPO (adiponectin), TNF (tumor necrosis factor) and NR3C1 (nuclear receptor subfamily 3, group C, member 1)) link the KEGG (Kyoto Encyclopedia of Genes and Genomes) "adipocytokine signaling pathway" with the BioCarta "visceral fat deposits and the metabolic syndrome" pathway to form a joint pathway. In total, the joint pathway contains 43 genes, among which 39 genes are related to eating disorder. As the first comprehensive gene resource for eating disorder, EDdb (http://eddb.cbi.pku.edu.cn) enables the exploration of gene-disease relationships and cross-talk mechanisms between related disorders. Through pathway statistical studies, we revealed that abnormal body weight caused by eating disorder and obesity may both be related to dysregulation of the novel joint pathway of adipocytokine signaling. In addition, this joint pathway may be the common pathway for body weight regulation in complex human diseases related to unhealthy lifestyle.; Biology; SCI(E); PubMed; 3; ARTICLE; 12; 1086-1096; 56
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/162459]
专题	生命科学学院
推荐引用方式 GB/T 7714	Zhao Min,Li XiaoMo,Qu Hong. EDdb: A web resource for eating disorder and its application to identify an extended adipocytokine signaling pathway related to eating disorder[J]. science china life sciences,2013.
APA	Zhao Min,Li XiaoMo,&Qu Hong.(2013).EDdb: A web resource for eating disorder and its application to identify an extended adipocytokine signaling pathway related to eating disorder.science china life sciences.
MLA	Zhao Min,et al."EDdb: A web resource for eating disorder and its application to identify an extended adipocytokine signaling pathway related to eating disorder".science china life sciences (2013).