小鼠生殖细胞的胚胎发育

doi:10.3321/j.issn:0253-9772.2002.01.018

CORC > 北京大学 > 生命科学学院

	小鼠生殖细胞的胚胎发育; Germ Cells in the Murine Embryonic Development
	韩嵘 ; 尚克刚
刊名	遗传
	2002
关键词	原始生殖细胞小鼠胚胎发育
DOI	10.3321/j.issn:0253-9772.2002.01.018
英文摘要	本文综述了近年来小鼠胚胎发育过程中生殖细胞的起源、迁移与增殖、性别分化及其基因组修饰等方面的研究进展.小鼠生殖细胞在7～7.5dpc时由原始生殖细胞(PGC)演变而来,至12.5dpc时PGC全部迁移进入生殖嵴,到13.5dpc时停止分裂.Steel/c-kit信号途径在PGC迁移过程中起重要作用.生殖细胞的性别主要是由生殖腺中体细胞的微环境决定的.Y染色体上存在精子形成所必需的基因.生殖细胞的全基因组范围的重新甲基化晚于胚胎体细胞的重新甲基化,到18.5dpc时才完成.雌性生殖细胞的X染色体重新活化在14.5～15.5dpc时完成,并且与生殖嵴的性别分化无关.; This paper reviewed the recent progress of the origin, migration and proliferation, sex determination, and genomic modification of murine germ cells during its embryonic development. Murine germ cells originate from primordial germ cells at about 7-7.5dpc. Then PGCs migrated into germinal ridge at about 12.5dpc during which Steel/c-kit signal pathway plays important roles and stopped division at 13.5dpc. The sex of germ cells was mainly determined by the soma microenvironment in the gonad. And there are essential genes for sperm formation on the Y chromosome. The de novo methylation of murine germ cells was much later than soma cells and was completed at about 18.5dpc. The X chromosome reactivation of female germ cells was finished at about 14.5-15.5dpc which was independent of sexual differentiation of germinal ridge.; 国家自然科学基金; PubMed; 中文核心期刊要目总览(PKU); 中国科学引文数据库(CSCD); 0; 1; 77-81; 24
语种	中文
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/45586]
专题	生命科学学院
推荐引用方式 GB/T 7714	韩嵘,尚克刚. 小鼠生殖细胞的胚胎发育, Germ Cells in the Murine Embryonic Development[J]. 遗传,2002.
APA	韩嵘,&尚克刚.(2002).小鼠生殖细胞的胚胎发育.遗传.
MLA	韩嵘,et al."小鼠生殖细胞的胚胎发育".遗传 (2002).