Blood Clearance, Distribution, Transformation, Excretion, and Toxicity   of Near-Infrared Quantum Dots Ag2Se in Mice

doi:10.1021/acsami.6b05057

CORC > 北京大学 > 化学与分子工程学院

	Blood Clearance, Distribution, Transformation, Excretion, and Toxicity of Near-Infrared Quantum Dots Ag2Se in Mice
	Tang, Huan ; Yang, Sheng-Tao ; Yang, Yi-Fan ; Ke, Da-Ming ; Liu, Jia-Hui ; Chen, Xing ; Wang, Haifang ; Liu, Yuanfang
刊名	ACS APPLIED MATERIALS & INTERFACES
	2016
关键词	Ag2Se quantum dots blood clearance biodistribution biotransformation toxicity IN-VIVO BIODISTRIBUTION CARBON NANOTUBES SILVER CELLS FATE PHARMACOKINETICS NANOPARTICLES NANOCRYSTALS FLUORESCENCE DEGRADATION
DOI	10.1021/acsami.6b05057
英文摘要	As a novel fluorescent probe in the second near-infrared window, Ag2Se quantum dots (QDs) exhibit great prospect in in vivo imaging due to their maximal penetration depth and negligible background. However, the in vivo behavior and toxicity of Ag2Se QDs still largely remain unknown, which severely hinders their wide-ranging biomedical applications. Herein, we systematically studied the blood clearance, distribution, transformation, excretion, and toxicity of polyethylene glycol (PEG) coated Ag2Se QDs in mice after intravenous administration with a high dose of 8 mu mol/kg body weight. QDs are quickly cleared from the blood with a circulation half-life of 0.4 h. QDs mainly accumulate in liver and spleen and are remarkably transformed into Ag and Se within 1 week. Ag is excreted from the body readily through both feces and urine, whereas Se is excreted hardly. The toxicological evaluations demonstrate that there is no overt acute toxicity of Ag2Se QDs to mice. Moreover, in regard to the in vivo stability problem of Ag2Se QDs, the biotransformation and its related metabolism are intensively discussed, and some promising coating means for Ag2Se QDs to avert transformation are proposed as well. Our work lays a solid foundation for safe applications of Ag2Se QDs in bioimaging in the future.; National Basic Research Program of China [2016YFA0201600, 2011CB933402]; Chinese Natural Science Foundation [31571024]; Top-notch Young Talents Program of China; SCI(E); EI; PubMed; ARTICLE; hwang@shu.edu.cn; yliu@pku.edu.cn; 28; 17859-17869; 8
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/493593]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Tang, Huan,Yang, Sheng-Tao,Yang, Yi-Fan,et al. Blood Clearance, Distribution, Transformation, Excretion, and Toxicity of Near-Infrared Quantum Dots Ag2Se in Mice[J]. ACS APPLIED MATERIALS & INTERFACES,2016.
APA	Tang, Huan.,Yang, Sheng-Tao.,Yang, Yi-Fan.,Ke, Da-Ming.,Liu, Jia-Hui.,...&Liu, Yuanfang.(2016).Blood Clearance, Distribution, Transformation, Excretion, and Toxicity of Near-Infrared Quantum Dots Ag2Se in Mice.ACS APPLIED MATERIALS & INTERFACES.
MLA	Tang, Huan,et al."Blood Clearance, Distribution, Transformation, Excretion, and Toxicity of Near-Infrared Quantum Dots Ag2Se in Mice".ACS APPLIED MATERIALS & INTERFACES (2016).