An interface for online coupling capillary electrophoresis to dielectric   barrier discharge ionization mass spectrometry

doi:10.1007/s00216-016-9822-3

CORC > 北京大学 > 化学与分子工程学院

	An interface for online coupling capillary electrophoresis to dielectric barrier discharge ionization mass spectrometry
	Zhang, Yiding ; Ai, Wanpeng ; Bai, Yu ; Zhou, Yinglin ; Wen, Luhong ; Zhang, Xinxiang ; Liu, Huwei
刊名	ANALYTICAL AND BIOANALYTICAL CHEMISTRY
	2016
关键词	Dielectric barrier discharge ionization Capillary electrophoresis Ambient mass spectrometry Interface SURFACE-PLASMON RESONANCE ELECTROSPRAY-IONIZATION ION-SOURCE COMBINATION
DOI	10.1007/s00216-016-9822-3
英文摘要	The online combination of capillary electrophoresis (CE) with mass spectrometry (MS) has long been desired for the capability of direct and simultaneous separation and detection with high efficiency, accuracy, and throughput. In this work, a novel CE-MS interface was developed, using dielectric barrier discharge ionization (DBDI). The interface employed a spray tip with a coaxial three-layer structure, into which the CE sample solution, the sheath liquid, and the nebulizing gas were introduced. The spray tip was put between the DBDI outlet and the MS inlet, thus the CE sample solution could be blended with the sheath liquid, then nebulized. The nebulized sample could be ionized by DBDI, and finally analyzed by MS. The key parameters of the interface were optimized. Then, proof-of-concept experiments separating and detecting the mixture of metronidazole and acetaminophen solutions were conducted. The results showed high separation efficiency, low time consumption, high reproducibility, and convenience in operation. In addition, the interface exhibited a high tolerance of non-volatile salts and surfactants, which would be widely used in CE analyses. All of these results demonstrated that the newly developed CE-DBDI-MS interface could be successfully used in CE-MS studies, and could be further utilized in multiple areas involving efficient separation and detection.; National Natural Science Foundation of China [21275012, 21527809]; SCI(E); PubMed; ARTICLE; yu.bai@pku.edu.cn; hwliu@pku.edu.cn; 30; 8655-8661; 408
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/493339]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Zhang, Yiding,Ai, Wanpeng,Bai, Yu,et al. An interface for online coupling capillary electrophoresis to dielectric barrier discharge ionization mass spectrometry[J]. ANALYTICAL AND BIOANALYTICAL CHEMISTRY,2016.
APA	Zhang, Yiding.,Ai, Wanpeng.,Bai, Yu.,Zhou, Yinglin.,Wen, Luhong.,...&Liu, Huwei.(2016).An interface for online coupling capillary electrophoresis to dielectric barrier discharge ionization mass spectrometry.ANALYTICAL AND BIOANALYTICAL CHEMISTRY.
MLA	Zhang, Yiding,et al."An interface for online coupling capillary electrophoresis to dielectric barrier discharge ionization mass spectrometry".ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2016).