Rational Design of Fluorescent Phthalazinone Derivatives for One- and Two-Photon Imaging | |
Yang, Lingfei ; Zhu, Yuanjun ; Shui, Mengyang ; Zhou, Tongliang ; Cai, Yuanbo ; Wang, Wei ; Xu, Fengrong ; Niu, Yan ; Wang, Chao ; Zhang, Jun-Long ; Xu, Ping ; Yuan, Lan ; Liang, Lei | |
刊名 | CHEMISTRY-A EUROPEAN JOURNAL |
2016 | |
关键词 | density functional calculations fluorescence microscopy fluorescent probes imaging agents synthesis design POSITIVE INOTROPIC AGENTS CONGESTIVE-HEART-FAILURE PYRIDAZINONE DERIVATIVES CARDIOTONIC AGENTS THERMAL-PROPERTIES N-ARYLATION POTENT PROBES CHEMISTRY 4,5-DIHYDRO-6-< 4-(1H-IMIDAZOL-1-YL)PHENYL> -3(2H)-PYRIDAZINONES |
DOI | 10.1002/chem.201601499 |
英文摘要 | Phthalazinone derivatives were designed as optical probes for one- and two-photon fluorescence microscopy imaging. The design strategy involves stepwise extension and modification of pyridazinone by 1)expansion of pyridazinone to phthalazinone, a larger conjugated system, as the electron acceptor, 2)coupling of electron-donating aromatic groups such as N,N-diethylaminophenyl, thienyl, naphthyl, and quinolyl to the phthalazinone, and 3)anchoring of an alkyl chain to the phthalazinone with various terminal substituents such as triphenylphosphonio, morpholino, triethylammonio, N-methylimidazolio, pyrrolidino, and piperidino. Theoretical calculations were utilized to verify the initial design. The desired fluorescent probes were synthesized by two different routes in considerable yields. Twenty-two phthalazinone derivatives were synthesized and their photophysical properties were measured. Selected compounds were applied in cell imaging, and valuable information was obtained. Furthermore, the designed compounds showed excellent performance in two-photon microscopic imaging of mouse brain slices.; National Natural Science Foundation of China [21202003, 21172012, 81302763, 91330103]; National Basic Research Program of China [2012CB518000]; Specialized Research Fund for the Doctoral Program of Higher Education of China [20120001110010]; SCI(E); EI; PubMed; ARTICLE; pingxu@bjmu.edu.cn; yuan_lan@bjmu.edu.cn; leiliang@bjmu.edu.cn; 35; 12363-12370; 22 |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://ir.pku.edu.cn/handle/20.500.11897/491552] |
专题 | 化学与分子工程学院 |
推荐引用方式 GB/T 7714 | Yang, Lingfei,Zhu, Yuanjun,Shui, Mengyang,et al. Rational Design of Fluorescent Phthalazinone Derivatives for One- and Two-Photon Imaging[J]. CHEMISTRY-A EUROPEAN JOURNAL,2016. |
APA | Yang, Lingfei.,Zhu, Yuanjun.,Shui, Mengyang.,Zhou, Tongliang.,Cai, Yuanbo.,...&Liang, Lei.(2016).Rational Design of Fluorescent Phthalazinone Derivatives for One- and Two-Photon Imaging.CHEMISTRY-A EUROPEAN JOURNAL. |
MLA | Yang, Lingfei,et al."Rational Design of Fluorescent Phthalazinone Derivatives for One- and Two-Photon Imaging".CHEMISTRY-A EUROPEAN JOURNAL (2016). |
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