Computational design of ligand-binding proteins | |
Yang, Wei ; Lai, Luhua | |
刊名 | CURRENT OPINION IN STRUCTURAL BIOLOGY |
2017 | |
关键词 | ENZYME DESIGN TRANSCRIPTION FACTORS MOLECULAR-DYNAMICS HIGH-AFFINITY DOCKING SPECIFICITY SELECTIVITY TARGETS SITES |
DOI | 10.1016/j.sbi.2016.11.021 |
英文摘要 | Custom-designed ligand-binding proteins with novel functions hold the potential for numerous applications. In recent years, the developments of computational methods together with high-throughput experimental screening techniques have led to the generation of novel, high-affinity ligand-binding proteins for given ligands. In addition, naturally occurring ligand-binding proteins have been computationally designed to recognize new ligands while keeping their original biological functions at the same time. Furthermore, metalloproteins have been successfully designed for novel functions and applications. Though much has been learned in these successful design cases, advances in our understanding of protein dynamics and functions related to ligand binding and development of novel computational strategies are necessary to further increase the success rate of computational protein-ligand binding design.; Ministry of Science and Technology of China [2015CB910300, 2016YFA0502303]; National Natural Science Foundation of China [21633001]; SCI(E); ARTICLE; 67-73; 45 |
语种 | 英语 |
内容类型 | 期刊论文 |
源URL | [http://ir.pku.edu.cn/handle/20.500.11897/484859] |
专题 | 化学与分子工程学院 生命科学学院 |
推荐引用方式 GB/T 7714 | Yang, Wei,Lai, Luhua. Computational design of ligand-binding proteins[J]. CURRENT OPINION IN STRUCTURAL BIOLOGY,2017. |
APA | Yang, Wei,&Lai, Luhua.(2017).Computational design of ligand-binding proteins.CURRENT OPINION IN STRUCTURAL BIOLOGY. |
MLA | Yang, Wei,et al."Computational design of ligand-binding proteins".CURRENT OPINION IN STRUCTURAL BIOLOGY (2017). |
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