Minimizing the Heat Effect of Photodynamic Therapy Based on Inorganic   Nanocomposites Mediated by 808 nm Near-Infrared Light

doi:10.1002/smll.201700038

CORC > 北京大学 > 化学与分子工程学院

	Minimizing the Heat Effect of Photodynamic Therapy Based on Inorganic Nanocomposites Mediated by 808 nm Near-Infrared Light
	Chan, Ming-Hsien ; Pan, Yu-Ting ; Lee, I-Jung ; Chen, Chieh-Wei ; Chan, Yung-Chieh ; Hsiao, Michael ; Wang, Feng ; Sun, Lingdong ; Chen, Xueyuan ; Liu, Ru-Shi
刊名	SMALL
	2017
关键词	808 nm near-infrared light bioimaging graphitic carbon nitride quantum dots photodynamic therapy upconversion nanoparticles UP-CONVERSION-NANOPARTICLES GRAPHENE QUANTUM DOTS NANO-BIOPROBES CANCER LUMINESCENCE NANOPROBES
DOI	10.1002/smll.201700038
英文摘要	Photodynamic therapy (PDT) based on photosensitizers (PSs) constructed with nanomaterials has become popular in cancer treatment, especially oral carcinoma cell. This therapy is characterized by improved PS accumulation in tumor regions and generation of reactive oxygen species (ROS) for PDT under specific excitation. In the selection of near-infrared (NIR) window, 808 nm NIR light because it can avoid the absorption of water is particularly suitable for the application in PDT. Hence, multiband emissions under a single 808 nm near-infrared excitation of Nd3+-sensitized upconversion nanoparticles (808 nm UCNPs) have been applied for the PDT effect. 808 nm UCNPs serve as light converter to emit UV light to excite inorganic PS, graphitic carbon nitride quantum dots (CNQDs), thereby generating ROS. In this study, a nanocomposite consisting UCNPs conjugated with poly-l-lysine (PLL) to improve binding with CNQDs is fabricated. According to the research results, NIR-triggered nanocomposites of 808 nm UCNP-PLL@CNs have been verified by significant improvement in ROS generation. Consequently, 808 nm UCNP-PLL@CNs exhibit high capability for ROS production and efficient PDT in vitro and in vivo. Moreover, the mechanism of PDT treatment by 808 nm UCNP-PLL@CNs is evaluated using the cell apoptosis pathway.; Ministry of Science and Technology of Taiwan [MOST 104-2113-M-002-012-MY3]; Academia Sinica [AS-103-TP-A06]; NSFC [U1305244, 21325104]; Academia Sinica; Ministry of Science and Technology [MOST 104-0210-01-09-02, MOST 105-0210-01-13-01, MOST 106-0210-01-15-02]; CAS/SAFEA International Partnership Program for Creative Research Teams; Research Grants Council of Hong Kong [CityU 109413]; SCI(E); ARTICLE; 21; 13
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/472888]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Chan, Ming-Hsien,Pan, Yu-Ting,Lee, I-Jung,et al. Minimizing the Heat Effect of Photodynamic Therapy Based on Inorganic Nanocomposites Mediated by 808 nm Near-Infrared Light[J]. SMALL,2017.
APA	Chan, Ming-Hsien.,Pan, Yu-Ting.,Lee, I-Jung.,Chen, Chieh-Wei.,Chan, Yung-Chieh.,...&Liu, Ru-Shi.(2017).Minimizing the Heat Effect of Photodynamic Therapy Based on Inorganic Nanocomposites Mediated by 808 nm Near-Infrared Light.SMALL.
MLA	Chan, Ming-Hsien,et al."Minimizing the Heat Effect of Photodynamic Therapy Based on Inorganic Nanocomposites Mediated by 808 nm Near-Infrared Light".SMALL (2017).