Peptide-conjugated PEGylated PAMAM as a highly affinitive nanocarrier   towards HER2-overexpressing cancer cells

doi:10.1039/c6ra19552k

CORC > 北京大学 > 化学与分子工程学院

	Peptide-conjugated PEGylated PAMAM as a highly affinitive nanocarrier towards HER2-overexpressing cancer cells
	Rostami, Iman ; Zhao, ZiJian ; Wang, Zihua ; Zhang, WeiKai ; Zhong, Yeteng ; Zeng, Qiang ; Jia, XinRu ; Hu, ZhiYuan
刊名	RSC ADVANCES
	2016
关键词	ANTICANCER DRUG-DELIVERY IN-VITRO EVALUATION GENE DELIVERY NANOPARTICLES DOXORUBICIN DENDRIMERS LIPOSOMES SYSTEM TUMOR LIGAND
DOI	10.1039/c6ra19552k
英文摘要	Numerous effective polymers have been designed for drug and gene delivery; of these, dendrimers have been a superior nanoplatform for targeted delivery to cancerous tumor cells. Doxorubicin (DOX) is an effective first-line antineoplastic drug encapsulated by dendrimers, which may improve its biological half-life and nonspecific distribution for different cancer treatments. In this investigation, an efficient HER2-targeting nanocarrier was developed with peptide YLFFVFER (H6) functionalized PAMAM dendrimers, which could specifically transport DOX to breast cancer cells. The peptide H6 was proportionally conjugated on the peripheral side of G4 PAMAM dendrimers using bifunctional polyethylene glycol (PEG). Toxicity testing showed that the nanocarriers were nearly non-toxic, whereas the DOX-loaded nanocarriers retained high cytotoxicity for the target cells. Detection of the nanocarriers' affinity towards the HER2 protein was performed by surface plasmon resonance imaging (SPRi), and the resulting equilibrium dissociation constant (K-D value) was 7.4810 x 10(-10) M.; National Natural Science Foundation of China [31470049, 31270875]; National High Technology Research and Development Program of China [2015AA020408]; "Strategic Priority Research Program" of Chinese Academy of Sciences [XDA09040300]; CAS-TWAS president's fellowship; SCI(E); ARTICLE; zq301@126.com; xrjia@pku.edu.cn; huzy@nanoctr.cn; 109; 107337-107343; 6
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/459132]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Rostami, Iman,Zhao, ZiJian,Wang, Zihua,et al. Peptide-conjugated PEGylated PAMAM as a highly affinitive nanocarrier towards HER2-overexpressing cancer cells[J]. RSC ADVANCES,2016.
APA	Rostami, Iman.,Zhao, ZiJian.,Wang, Zihua.,Zhang, WeiKai.,Zhong, Yeteng.,...&Hu, ZhiYuan.(2016).Peptide-conjugated PEGylated PAMAM as a highly affinitive nanocarrier towards HER2-overexpressing cancer cells.RSC ADVANCES.
MLA	Rostami, Iman,et al."Peptide-conjugated PEGylated PAMAM as a highly affinitive nanocarrier towards HER2-overexpressing cancer cells".RSC ADVANCES (2016).