PAA修饰的GdF_3纳米片作为MRI和CT双模式成像造影剂的研究（英文）

doi:10.1007/s11434-015-0802-3

CORC > 北京大学 > 化学与分子工程学院

	PAA修饰的GdF_3纳米片作为MRI和CT双模式成像造影剂的研究（英文）; PAA-capped GdF3 nanoplates as dual-mode MRI and CT contrast agents
	郑晓宇 ; 孙聆东 ; 郑弢 ; 董浩 ; 李洋 ; 王也夫 ; 严纯华
刊名	Science Bulletin
	2015
关键词	Nanoplates GdF 3 Contrast agent MRI CT Nanoplates GdF3 Contrast agent MRI CT UP-CONVERSION LUMINESCENCE RAY COMPUTED-TOMOGRAPHY FLUORIDE NANOCRYSTALS GADOLINIUM OXIDE NANOPARTICLES NANOPROBES RELAXIVITY DENDRIMER WATER ACID
DOI	10.1007/s11434-015-0802-3
英文摘要	Aiming at improving the sensitivity and accuracy of diagnosis, the combination of magnetic resonance imaging(MRI) and X-ray computed tomography(CT) in a single probe is in urgent need. Here, we report the development of polyacrylic acid(PAA)-capped Gd F3nanoplates(NPs) as novel MRI and CT dual-mode ...; Aiming at improving the sensitivity and accuracy of diagnosis, the combination of magnetic resonance imaging (MRI) and X-ray computed tomography (CT) in a single probe is in urgent need. Here, we report the development of polyacrylic acid (PAA)-capped GdF3 nanoplates (NPs) as novel MRI and CT dual-mode contrast agents (CAs) with high longitudinal relaxivity (r (1)) and large X-ray attenuation coefficient. Uniform GdF3 rhombic NPs were fabricated by controlling reaction conditions and introducing dopants. The average size of GdF3 NPs is (10.6 +/- A 1.1) nm in long diagonal, (7.0 +/- A 0.8) nm in short diagonal, and (4.2 +/- A 1.2) nm in thickness. Ligand-exchange treatment was performed to render the NPs water-dispersible. The r (1) of PAA-capped GdF3 NPs (15.8 L/(mmol s)) is four times higher than that of clinically used Gd-DTPA. We suppose that the high r (1) value originates from the construction of two-dimensional (2D) nanostructures, which endows nanocrystals with larger surface areas and longer rotational correlation time than those of sphere nanostructures with the same volume. The CT contrast enhancement ability of PAA-capped GdF3 NPs was evaluated in comparison with clinically used Iohexol. The above results suggest that the PAA-capped GdF3 NPs could serve as CAs for MRI and CT dual-mode imaging.; SCI(E); 中国科学引文数据库(CSCD); sun@pku.edu.cn; yan@pku.edu.cn; 12; 1092-1100; 60
语种	中文
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/451372]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	郑晓宇,孙聆东,郑弢,等. PAA修饰的GdF_3纳米片作为MRI和CT双模式成像造影剂的研究（英文）, PAA-capped GdF3 nanoplates as dual-mode MRI and CT contrast agents[J]. Science Bulletin,2015.
APA	郑晓宇.,孙聆东.,郑弢.,董浩.,李洋.,...&严纯华.(2015).PAA修饰的GdF_3纳米片作为MRI和CT双模式成像造影剂的研究（英文）.Science Bulletin.
MLA	郑晓宇,et al."PAA修饰的GdF_3纳米片作为MRI和CT双模式成像造影剂的研究（英文）".Science Bulletin (2015).