Metabolic Remodeling of Cell-Surface Sialic Acids: Principles,   Applications, and Recent Advances

doi:10.1002/cbic.201500344

CORC > 北京大学 > 化学与分子工程学院

	Metabolic Remodeling of Cell-Surface Sialic Acids: Principles, Applications, and Recent Advances
	Cheng, Bo ; Xie, Ran ; Dong, Lu ; Chen, Xing
刊名	CHEMBIOCHEM
	2016
关键词	bioorthogonal chemistry chemical reporters click chemistry metabolic glycan labeling sialic acids ACYL SIDE-CHAIN BIOORTHOGONAL CHEMICAL REPORTERS N-ACETYLMANNOSAMINE ANALOGS FREE CLICK CHEMISTRY POLYSIALIC ACID IN-VIVO CROSS-LINKING LIVING ANIMALS D-MANNOSAMINE CANCER-CELLS
DOI	10.1002/cbic.201500344
英文摘要	Cell-surface sialic acids are essential in mediating a variety of physiological and pathological processes. Sialic acid chemistry and biology remain challenging to investigate, demanding new tools for probing sialylation in living systems. The metabolic glycan labeling (MGL) strategy has emerged as an invaluable chemical biology tool that enables metabolic installation of useful functionalities into cell-surface sialoglycans by hijacking the sialic acid biosynthetic pathway. Here we review the principles of MGL and its applications in study and manipulation of sialic acid function, with an emphasis on recent advances.; National Natural Science Foundation of China [21172013, 91127034, 91313301]; National Basic Research Program of China [2012CB917303]; National Instrumentation Program [2011YQ030124]; SCI(E); REVIEW; xingchen@pku.edu.cn; 1; 11-27; 17
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/439004]
专题	化学与分子工程学院生命科学学院
推荐引用方式 GB/T 7714	Cheng, Bo,Xie, Ran,Dong, Lu,et al. Metabolic Remodeling of Cell-Surface Sialic Acids: Principles, Applications, and Recent Advances[J]. CHEMBIOCHEM,2016.
APA	Cheng, Bo,Xie, Ran,Dong, Lu,&Chen, Xing.(2016).Metabolic Remodeling of Cell-Surface Sialic Acids: Principles, Applications, and Recent Advances.CHEMBIOCHEM.
MLA	Cheng, Bo,et al."Metabolic Remodeling of Cell-Surface Sialic Acids: Principles, Applications, and Recent Advances".CHEMBIOCHEM (2016).