Enantioselective Total Syntheses of Kuwanon X, Kuwanon Y, and Kuwanol A

doi:10.1021/acs.orglett.5b03285

CORC > 北京大学 > 化学与分子工程学院

	Enantioselective Total Syntheses of Kuwanon X, Kuwanon Y, and Kuwanol A
	Gao, Lei ; Han, Jianguang ; Lei, Xiaoguang
刊名	ORGANIC LETTERS
	2016
关键词	DIELS-ALDER REACTION CULTIVATED MULBERRY TREE MORUS-LHOU KOIDZ STILBENE DERIVATIVES NATURAL-PRODUCTS LEWIS-ACID STEM BARK ALBA L ADDUCTS CATALYSIS
DOI	10.1021/acs.orglett.5b03285
英文摘要	The first enantioselective total syntheses of (-)-kuwanon X, (+)-kuwanon Y, and (+)-kuwanol A have been accomplished by using asymmetric Diels-Alder cyclo-addition promoted by chiral VANOL or VAPOL/boron Lewis acid. The biosynthesis-inspired asymmetric Diels-Alder cyclo-addition shows high exo selectivity (exo/endo = 13/1), which was unprecedented in the previous total syntheses of related prenylflavonoid Diels-Alder natural products. An acid catalyzed intramolecular ketalization process enabled a biomimetic transformation to construct the polycyclic skeleton of kuwanol A efficiently.; National High Technology Project 973 [2015CB856200]; NNSFC [21222209, 91313303, 21472010, 21561142002]; SCI(E); ARTICLE; xglei@pku.edu.cn; 3; 360-363; 18
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/438662]
专题	化学与分子工程学院生命科学学院
推荐引用方式 GB/T 7714	Gao, Lei,Han, Jianguang,Lei, Xiaoguang. Enantioselective Total Syntheses of Kuwanon X, Kuwanon Y, and Kuwanol A[J]. ORGANIC LETTERS,2016.
APA	Gao, Lei,Han, Jianguang,&Lei, Xiaoguang.(2016).Enantioselective Total Syntheses of Kuwanon X, Kuwanon Y, and Kuwanol A.ORGANIC LETTERS.
MLA	Gao, Lei,et al."Enantioselective Total Syntheses of Kuwanon X, Kuwanon Y, and Kuwanol A".ORGANIC LETTERS (2016).