Noninvasive Surface Detection of Papillary Thyroid Carcinoma by Fourier   Transform Infrared Spectroscopy

doi:10.1007/s40242-015-4354-5

CORC > 北京大学 > 化学与分子工程学院

	Noninvasive Surface Detection of Papillary Thyroid Carcinoma by Fourier Transform Infrared Spectroscopy
	Zhang Weitao ; Tian Peirong ; Zhu Qing ; Zhang Yuanfu ; Cui Long ; Xu Zhi
刊名	CHEMICAL RESEARCH IN CHINESE UNIVERSITIES
	2015
关键词	Noninvasive detection Papillary thyroid carcinoma Fourier transform infrared(FTIR) spectroscopy Fisher&apos CANCER MICROSPECTROSCOPY NODULE CELLS s discriminant analysis
DOI	10.1007/s40242-015-4354-5
英文摘要	Previously Fourier transform infrared(FTIR) spectroscopy has been applied to detecting thyroid cancer during operations and to discriminating cervical metastatic ones from non-metastatic lymph nodes. This study explored the possibility of establishing a sensitive, accurate and noninvasive screen or diagnosis by preoperative FTIR spectroscopy. 111 patients undergone a thyroid operation and 50 healthy volunteers were enrolled in the study. The FTIR spectra were obtained by two mid-infrared optical fibers with an attenuated total reflectance(ATR) probe closely contacting the subjects' skin on the thyroid nodules. The FTIR spectra obtained from normal thyroid, nodular goiter(NG) and papillary thyroid carcinoma(PTC) patients were compared. A Fisher's discriminant analysis was created based on these data. There were 41 PTC patients and 70 NG patients according to their histopathological examinations. A total of 23(of 39) parameters were statistically different among the three groups(P<0.05). The F-1300 and F-1080 parameters were significantly different between the three groups. In total, 9 out of 39 FTIR parameters were selected as independent factors by the Wilks' lambda stepwise discriminant analysis. The discrimination accuracy of papillary thyroid carcinoma in the three groups was 88.8%. Surface detection of PTC by FTIR spectroscopy is feasible. FTIR spectroscopy can be used for rapid and noninvasive PTC screen and auxiliary diagnosis.; the Natural Science Foundation of Beijing City,China; the Clinical Research Project of Peking University Third Hospital,China; the Major Research Project of Peking University Third Hospital,China; SCI(E); 中国科技核心期刊(ISTIC); 中国科学引文数据库(CSCD); ARTICLE; xuzhi123456@sohu.com; 2; 198-202; 31
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/415350]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Zhang Weitao,Tian Peirong,Zhu Qing,et al. Noninvasive Surface Detection of Papillary Thyroid Carcinoma by Fourier Transform Infrared Spectroscopy[J]. CHEMICAL RESEARCH IN CHINESE UNIVERSITIES,2015.
APA	Zhang Weitao,Tian Peirong,Zhu Qing,Zhang Yuanfu,Cui Long,&Xu Zhi.(2015).Noninvasive Surface Detection of Papillary Thyroid Carcinoma by Fourier Transform Infrared Spectroscopy.CHEMICAL RESEARCH IN CHINESE UNIVERSITIES.
MLA	Zhang Weitao,et al."Noninvasive Surface Detection of Papillary Thyroid Carcinoma by Fourier Transform Infrared Spectroscopy".CHEMICAL RESEARCH IN CHINESE UNIVERSITIES (2015).