Spectroscopic and electrochemical studies of DNA breakage induced by   dopamine and copper ion

doi:10.2116/analsci.19.1099

CORC > 北京大学 > 化学与分子工程学院

	Spectroscopic and electrochemical studies of DNA breakage induced by dopamine and copper ion
	Liu, J ; Li, QW ; Yu, YD ; Fang, X
刊名	analytical sciences
	2003
关键词	DAMAGE APOPTOSIS MECHANISM BINDING CU(II) CELLS CU2+
DOI	10.2116/analsci.19.1099
英文摘要	Dopamine may show some biological activities in antitumor and cell apoptosis. Herein, we attempted to employ UV-Vis, CD, and electrochemical methods to investigate the interaction between DNA and dopamine. Both the spectroscopic and electrochemical evidence indicated that dopamine, which was a cation, could interact with polyanion DNA. However, this kind of interaction, mainly by a static electronic force, did not result in any damage of the DNA structure. This situation was quite different when Cu ion was added to the dopamine-DNA system; an obvious change in the color of the solution and in the spectra of UV-Vis and CD showed that some chemical changes occurred in this system, and that the DNA native structure was destroyed. The results of gel electrophores further revealed that DNA might be broken into small segments by dopamine in the presence of Cu ion. The possible reaction mechanisms are discussed.; Chemistry, Analytical; SCI(E); 12; ARTICLE; 8; 1099-1102; 19
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/401026]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Liu, J,Li, QW,Yu, YD,et al. Spectroscopic and electrochemical studies of DNA breakage induced by dopamine and copper ion[J]. analytical sciences,2003.
APA	Liu, J,Li, QW,Yu, YD,&Fang, X.(2003).Spectroscopic and electrochemical studies of DNA breakage induced by dopamine and copper ion.analytical sciences.
MLA	Liu, J,et al."Spectroscopic and electrochemical studies of DNA breakage induced by dopamine and copper ion".analytical sciences (2003).