SYNTHESIS OF BIOCOMPATIBLE POLYMERS WITH ASPIRIN-MOIETIES FOR ASPIRIN   DELIVERY

doi:10.1177/088391159100600203

CORC > 北京大学 > 化学与分子工程学院

	SYNTHESIS OF BIOCOMPATIBLE POLYMERS WITH ASPIRIN-MOIETIES FOR ASPIRIN DELIVERY
	LI, FM ; GU, ZW ; LI, GW ; WANG, S ; FENG, XD
刊名	生物活性与相容性聚合物杂志
	1991
DOI	10.1177/088391159100600203
英文摘要	Polyacrylate and polyhydroxylate polymers with aspirin moieties were prepared. The acrylate polymers were obtained by the synthesis and polymerization of several new monomers; beta-(acetylsalicylyloxy)ethyl methacrylate, beta-(acetylsalicylyloxy)propyl methacrylate, beta-(acetylsalicylyloxy)ethyl acrylate, beta-hydroxy-gamma-(acetylsalicylyloxy)ethyl methacrylate and beta-hydroxy-gamma-(acetylsalicylyloxy)propyl methacrylate. The second series of biocompatible polymers with aspirin moieties was prepared by reacting the hydroxyl group of poly(vinyl alcohol) and poly(allyl alcohol) with 1-(acetylsalicylyl)benzotriazole. Both the homogeneous and heterogeneous hydrolysis of eight biocompatible polymers and copolymer with aspirin moieties were investigated in acidic or alkaline medium at 37-degrees-C or 60-degrees-C, respectively. The main hydrolysis product was aspirin with minor amounts of salicylic acid. The release rates of aspirin and salicylic acid were related to the hydrolysis temperature, and the length of side chain. The release rate of aspirin and salicylic acid from poly[1-(acetylsalicylyloxy)ethyl methacrylate-co-methacrylic acid] is markedly dependent on polymer composition and the pH value of hydrolysis medium.; Biotechnology & Applied Microbiology; Materials Science, Biomaterials; Polymer Science; SCI(E); EI; 8; ARTICLE; 2; 142-163; 6
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/313561]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	LI, FM,GU, ZW,LI, GW,et al. SYNTHESIS OF BIOCOMPATIBLE POLYMERS WITH ASPIRIN-MOIETIES FOR ASPIRIN DELIVERY[J]. 生物活性与相容性聚合物杂志,1991.
APA	LI, FM,GU, ZW,LI, GW,WANG, S,&FENG, XD.(1991).SYNTHESIS OF BIOCOMPATIBLE POLYMERS WITH ASPIRIN-MOIETIES FOR ASPIRIN DELIVERY.生物活性与相容性聚合物杂志.
MLA	LI, FM,et al."SYNTHESIS OF BIOCOMPATIBLE POLYMERS WITH ASPIRIN-MOIETIES FOR ASPIRIN DELIVERY".生物活性与相容性聚合物杂志 (1991).