Large-pore mesoporous silica spheres: synthesis and application in HPLC

doi:10.1016/j.colsurfa.2003.08.010

CORC > 北京大学 > 化学与分子工程学院

	Large-pore mesoporous silica spheres: synthesis and application in HPLC
	Ma, YR ; Qi, LM ; Ma, JM ; Wu, YQ ; Liu, O ; Cheng, HM
刊名	colloids and surfaces a physicochemical and engineering aspects
	2003
关键词	mesoporous silica spheres triblock copolymer HPLC proteins MORPHOLOGICAL CONTROL LIQUID-CHROMATOGRAPHY SURFACTANT MCM-41 SBA-15 PARTICLES COPOLYMER TRIBLOCK SIZE
DOI	10.1016/j.colsurfa.2003.08.010
英文摘要	Large-pore mesoporous silica microspheres with tailored pore sizes were prepared via a two-step synthesis process by using a triblock copolymer EO20PO70EO20 as template in combination with a cosurfactant cetyltrimethylammonium bromide (CTAB) and a cosolvent ethanol. The obtained mesoporous silica spheres were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), and N-2 sorption. The pore size of the silica spheres was increased up to 9.8 nm with increasing the hydrothermal treatment temperature in the second step to 130degreesC. The presence of the cosolvent ethanol was found to be essential to the formation of mesoporous silica with a perfectly spherical morphology. Spherical mesoporous silica was successfully functionalized by dimethyloctadecylchlorosilane (C-18), leading to the formation of a C-18-modified spherical mesoporous silica. It has been shown that the C-18-modified mesoporous silica microspheres can be used as a good packing in high performance liquid chromatography (HPLC) to separate both small aromatic molecules and large biomolecules such as proteins. (C) 2003 Elsevier B.V. All rights reserved.; Chemistry, Physical; SCI(E); EI; 110; ARTICLE; 1-3; 1-8; 229
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/255810]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Ma, YR,Qi, LM,Ma, JM,et al. Large-pore mesoporous silica spheres: synthesis and application in HPLC[J]. colloids and surfaces a physicochemical and engineering aspects,2003.
APA	Ma, YR,Qi, LM,Ma, JM,Wu, YQ,Liu, O,&Cheng, HM.(2003).Large-pore mesoporous silica spheres: synthesis and application in HPLC.colloids and surfaces a physicochemical and engineering aspects.
MLA	Ma, YR,et al."Large-pore mesoporous silica spheres: synthesis and application in HPLC".colloids and surfaces a physicochemical and engineering aspects (2003).