Structure-activity relationships of novel endomorphin-2 analogues with   N-O turns induced by alpha-aminoxy acids

doi:10.1016/j.bmcl.2005.04.050

CORC > 北京大学 > 化学与分子工程学院

	Structure-activity relationships of novel endomorphin-2 analogues with N-O turns induced by alpha-aminoxy acids
	Wei, J ; Shao, X ; Gong, MZ ; Zhu, BB ; Cui, YX ; Gao, YF ; Wang, R
刊名	生物有机化学与医药化学通讯
	2005
关键词	endomorphin-2 opioid peptide N-O turn alpha-aminoxy acid simulation DELTA-OPIOID RECEPTOR HIGH-AFFINITY PEPTIDES DESIGN ENKEPHALIN CONFORMATION PREFERENCES SIMULATION MIMETICS DYNAMICS
DOI	10.1016/j.bmcl.2005.04.050
英文摘要	Endomorphin-2 (H-Tyr-Pro-Phe-Phe-NH2, EM-2) is a putative endogenous mu-opioid receptor ligand. To study the structure-activity relationship against its receptor, we introduced N-O turns into EM-2 and got the analogues with potent affinities for p-opioid receptor. Our results indicated that N-O turn structures at the PrO2-aminoxy-Phe(3) position of EM-2 analogues played important roles for their affinities. These novel analogues with N-O turns provided a new approach to develop potent analgesics related to EM-2. (c) 2005 Elsevier Ltd. All rights reserved.; Chemistry, Medicinal; Chemistry, Organic; SCI(E); 13; ARTICLE; 12; 2986-2989; 15
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/253370]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Wei, J,Shao, X,Gong, MZ,et al. Structure-activity relationships of novel endomorphin-2 analogues with N-O turns induced by alpha-aminoxy acids[J]. 生物有机化学与医药化学通讯,2005.
APA	Wei, J.,Shao, X.,Gong, MZ.,Zhu, BB.,Cui, YX.,...&Wang, R.(2005).Structure-activity relationships of novel endomorphin-2 analogues with N-O turns induced by alpha-aminoxy acids.生物有机化学与医药化学通讯.
MLA	Wei, J,et al."Structure-activity relationships of novel endomorphin-2 analogues with N-O turns induced by alpha-aminoxy acids".生物有机化学与医药化学通讯 (2005).