Cobalt(II) and cobalt(III) dipicolinate complexes: Solid state,   solution, and in vivo insulin-like properties

doi:10.1021/ic020062l

CORC > 北京大学 > 化学与分子工程学院

	Cobalt(II) and cobalt(III) dipicolinate complexes: Solid state, solution, and in vivo insulin-like properties
	Yang, LQ ; Crans, DC ; Miller, SM ; la Cour, A ; Anderson, OP ; Kaszynski, PM ; Godzala, ME ; Austin, LD ; Willsky, GR
刊名	inorganic chemistry
	2002
关键词	ORAL VANADYL SULFATE ELECTRON-TRANSFER PYRIDINE-2,6-DICARBOXYLIC ACID PARAMAGNETIC COBALT(II) METAL CARBOXYLATES DIABETES-MELLITUS MESSENGER-RNA CHEMISTRY CRYSTAL RATS
DOI	10.1021/ic020062l
英文摘要	The synthesis and characterization of Co(II) and Co(III) 2,6-pyridinedicarboxylate (dipic(2-)) complexes are reported. Solid-state X-ray characterizations were performed on [Co(H(2)dipic)(dipic)].3H(2)O and [Co(dipic)(mu-dipic)Co(H(2)O)(5)]. 2H(2)O. Two coordination modes not previously observed in dipicolinate transition metal complexes were observed in these complexes; one involves metal coordination to the short C-O (C=O) bond, and the other involves metal coordination to a protonated oxygen atom. Solution studies, including paramagnetic NMR and UV-vis spectroscopy, were done showing the high stability and low lability of the Co(III) complex, whereas the Co(II) complexes exhibited ligand exchange in the presence of excess ligand. The [Co(dipic)(2)](2-) complex has pH dependent lability and in this regard is most similar to the [VO(2)dipic](-) complex. The [Co(dipic)(2)](2-) was found to be effective in reducing the hyperlipidemia of diabetes using oral administration in drinking water in rats with STZ-induced diabetes. Oral administration Of VOSO(4) was used as a positive control for metal efficacy against diabetes. In addition to providing a framework to evaluate structure-function relationships of various transition metal complexes in alleviating the symptoms of diabetes, this work describes novel aspects of structural and solution cobalt chemistry.; Chemistry, Inorganic & Nuclear; SCI(E); 101; ARTICLE; 19; 4859-4871; 41
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/208469]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Yang, LQ,Crans, DC,Miller, SM,et al. Cobalt(II) and cobalt(III) dipicolinate complexes: Solid state, solution, and in vivo insulin-like properties[J]. inorganic chemistry,2002.
APA	Yang, LQ.,Crans, DC.,Miller, SM.,la Cour, A.,Anderson, OP.,...&Willsky, GR.(2002).Cobalt(II) and cobalt(III) dipicolinate complexes: Solid state, solution, and in vivo insulin-like properties.inorganic chemistry.
MLA	Yang, LQ,et al."Cobalt(II) and cobalt(III) dipicolinate complexes: Solid state, solution, and in vivo insulin-like properties".inorganic chemistry (2002).