Studies on a high encapsulation of colchicine by a niosome system

doi:10.1016/S0378-5173(02)00301-0

CORC > 北京大学 > 化学与分子工程学院

	Studies on a high encapsulation of colchicine by a niosome system
	Hao, YM ; Zhao, FL ; Li, N ; Yang, YH ; Li, K
刊名	international journal of pharmaceutics
	2002
关键词	drug carrier niosome colchicine 5-fluorouracil span 60 cholesterol NONIONIC SURFACTANT VESICLES IN-VITRO DRUG CARRIERS DELIVERY LIPOSOMES SPAN-60 MICE PK1
DOI	10.1016/S0378-5173(02)00301-0
英文摘要	To prepare niosomes which have high encapsulation capacity for soluble drugs, starting from Span 60 and cholesterol, an improved method, evaporation-sonication method, was proposed. The corresponding niosomes show a good stability at least 40 days. Colchicine was chosen as a model drug for examining the capsulation capacity of these niosomes. To obtain the highest encapsulation efficiency, several factors including the structure of surfactant, level of lipid, content of drug and cholesterol were investigated and optimized. The inner cause was also discussed. The results indicate that the Span 60 is the most ideal surfactant among four kinds of Span. Furthermore, the release studies of colchicine and 5-fluorouracil (5-FU) in vitro from niosomes exhibited a prolonged release profile as studied over a period of 24 h. The results demonstrated that niosomes prepared in this way not only have high encapsulation capacity but also is expected that side effects of drugs may be reduced. It still suggests that this method may be used extensively in the field of encapsulation soluble drugs. (C) 2002 Elsevier Science B.V. All rights reserved.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000178214300007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Pharmacology & Pharmacy; SCI(E); PubMed; 112; ARTICLE; 1-2; 73-80; 244
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/200428]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Hao, YM,Zhao, FL,Li, N,et al. Studies on a high encapsulation of colchicine by a niosome system[J]. international journal of pharmaceutics,2002.
APA	Hao, YM,Zhao, FL,Li, N,Yang, YH,&Li, K.(2002).Studies on a high encapsulation of colchicine by a niosome system.international journal of pharmaceutics.
MLA	Hao, YM,et al."Studies on a high encapsulation of colchicine by a niosome system".international journal of pharmaceutics (2002).