Radiation cross-linked collagen/dextran dermal scaffolds: effects of   dextran on cross-linking and degradation

doi:10.1080/09205063.2014.985023

CORC > 北京大学 > 化学与分子工程学院

	Radiation cross-linked collagen/dextran dermal scaffolds: effects of dextran on cross-linking and degradation
	Zhang, Yaqing ; Zhang, Xiangmei ; Xu, Ling ; Wei, Shicheng ; Zhai, Maolin
刊名	journal of biomaterials science polymer edition
	2015
关键词	radiation cross-linking artificial dermal substitutes scaffolds dermal tissue engineering collagen/dextran HYALURONIC ACID SCAFFOLDS GAMMA-IRRADIATION AQUEOUS-SOLUTIONS IN-VITRO SKIN HYDROGELS GLUTARALDEHYDE GLYCOSAMINOGLYCANS AGENTS FILMS
DOI	10.1080/09205063.2014.985023
英文摘要	Ionizing radiation effectively cross-links collagen into network with enhanced anti-degradability and biocompatibility, while radiation-cross-linked collagen scaffold lacks flexibility, satisfactory surface appearance, and performs poor in cell penetration and ingrowth. To make the radiation-cross-linked collagen scaffold to serve as an ideal artificial dermis, dextran was incorporated into collagen. Scaffolds with the collagen/dextran (Col/Dex) ratios of 10/0, 7/3, and 5/5 were fabricated via Co-60 gamma-irradiation cross-linking, followed by lyophilization. The morphology, microstructure, physicochemical, and biological properties were investigated. Compared with pure collagen, scaffolds with dextran demonstrated more porous appearance, enhanced hydrophilicity while the cross-linking density was lower with the consequence of larger pore size, higher water uptake, as well as reduced stiffness. Accelerated degradation was observed when dextran was incorporated in both the in vitro and in vivo assays, which led to earlier integration with cell and host tissue. The effect of dextran on degradation was ascribed to the decreased cross-linking density, looser microstructure, more porous and hydrophilic surface. Considering the better appearance, softness, moderate degradation rate due to controllable cross-linking degree and good biocompatibility as well, radiation-cross-linked collagen/dextran scaffolds are expected to serve as promising artificial dermal substitutes.; http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000347155600002&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=8e1609b174ce4e31116a60747a720701 ; Engineering, Biomedical; Materials Science, Biomaterials; Polymer Science; SCI(E); EI; PubMed; 0; ARTICLE; lingxu@pku.edu.cn; sc-wei@pku.edu.cn; 3; 162-180; 26
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/164070]
专题	化学与分子工程学院工学院
推荐引用方式 GB/T 7714	Zhang, Yaqing,Zhang, Xiangmei,Xu, Ling,et al. Radiation cross-linked collagen/dextran dermal scaffolds: effects of dextran on cross-linking and degradation[J]. journal of biomaterials science polymer edition,2015.
APA	Zhang, Yaqing,Zhang, Xiangmei,Xu, Ling,Wei, Shicheng,&Zhai, Maolin.(2015).Radiation cross-linked collagen/dextran dermal scaffolds: effects of dextran on cross-linking and degradation.journal of biomaterials science polymer edition.
MLA	Zhang, Yaqing,et al."Radiation cross-linked collagen/dextran dermal scaffolds: effects of dextran on cross-linking and degradation".journal of biomaterials science polymer edition (2015).