Intelligent nucleic acid delivery systems based on stimuli-responsive   polymers

doi:10.1039/b915020j

CORC > 北京大学 > 化学与分子工程学院

	Intelligent nucleic acid delivery systems based on stimuli-responsive polymers
	Du, Fu-Sheng ; Wang, Yang ; Zhang, Rui ; Li, Zi-Chen
刊名	软性材料
	2010
关键词	NONVIRAL GENE DELIVERY POLYELECTROLYTE COMPLEX MICELLES LOW-MOLECULAR-WEIGHT POLY(ETHYLENE GLYCOL)-SIRNA CONJUGATE CATIONIC FUSOGENIC PEPTIDE EFFICIENT SIRNA DELIVERY SMALL INTERFERING RNA PLASMID DNA DELIVERY IN-VIVO DRUG-DELIVERY
DOI	10.1039/b915020j
英文摘要	Despite significant advances in the past two decades, gene therapy is still in the stage of clinical trials worldwide mainly due to the lack of safe and efficient delivery vehicles for therapeutic nucleic acids. Among the various attempts to develop clinically applicable gene therapy, polymer-based nucleic acid delivery systems have attracted great interest, especially for the exciting RNAi-based gene therapy. Regarding in vivo nucleic acid delivery, in particular via intravenous injection, there are many extraand intracellular obstacles, some of which are conflicting. Virus-mimicking nucleic acid delivery systems that combine multiple and programmable functions are thought to be very promising for conquering these challenging barriers. In this review article, we highlight recent progress in stimuli-responsive polymers that have been applied in fabrication of non-viral multi-functional nucleic acid vehicles, which are categorized by the type of stimulus: reduction potential, pH, temperature, and others. In each section, intelligent pDNA delivery systems are introduced first, followed by summarizing various responsive polymer-based siRNA vehicles. Considering the great potential of RNAi-based gene therapy, we devote some space to the recent progress of multi-functional siRNA delivery systems. In addition, different requirements in designing polymer-based siRNA and pDNA carriers are also specified in this review.; Chemistry, Physical; Materials Science, Multidisciplinary; Physics, Multidisciplinary; Polymer Science; SCI(E); EI; 44; REVIEW; 5; 835-848; 6
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/151229]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Du, Fu-Sheng,Wang, Yang,Zhang, Rui,et al. Intelligent nucleic acid delivery systems based on stimuli-responsive polymers[J]. 软性材料,2010.
APA	Du, Fu-Sheng,Wang, Yang,Zhang, Rui,&Li, Zi-Chen.(2010).Intelligent nucleic acid delivery systems based on stimuli-responsive polymers.软性材料.
MLA	Du, Fu-Sheng,et al."Intelligent nucleic acid delivery systems based on stimuli-responsive polymers".软性材料 (2010).