Quinoline-4-methyl esters as human nonpancreatic secretory phospholipase   A(2) inhibitors

doi:10.1016/j.bmc.2011.04.039

CORC > 北京大学 > 化学与分子工程学院

	Quinoline-4-methyl esters as human nonpancreatic secretory phospholipase A(2) inhibitors
	Wu, Yiran ; Chen, Zheng ; Liu, Ying ; Yu, Lanlan ; Zhou, Lu ; Yang, Suijia ; Lai, Luhua
刊名	生物有机化学与医药化学
	2011
关键词	Quinoline-4-methyl esters Human nonpancreatic secretory phospholipase A(2) inhibitor Synthesis Bioassay Molecular model 1ST POTENT COMPLEXES DESIGN MODEL
DOI	10.1016/j.bmc.2011.04.039
英文摘要	A series of novel fused heterocycle methyl esters were designed and synthesized as human nonpancreatic secretory phospholipase A(2) (hnps-PLA(2)) competitive inhibitors. Among the 22 synthesized compounds, 17 quinoline-4-methyl esters displayed hnps-PLA(2) inhibition activity in the in vitro bioassay. The IC50 value for the best compound 3o was 1.5 mu M. The structure-inhibition-activity relationships of the compounds were studied using molecular docking. Crown Copyright (C) 2011 Published by Elsevier Ltd. All rights reserved.; Biochemistry & Molecular Biology; Chemistry, Medicinal; Chemistry, Organic; SCI(E); PubMed; 4; ARTICLE; 11; 3361-3366; 19
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/149984]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Wu, Yiran,Chen, Zheng,Liu, Ying,et al. Quinoline-4-methyl esters as human nonpancreatic secretory phospholipase A(2) inhibitors[J]. 生物有机化学与医药化学,2011.
APA	Wu, Yiran.,Chen, Zheng.,Liu, Ying.,Yu, Lanlan.,Zhou, Lu.,...&Lai, Luhua.(2011).Quinoline-4-methyl esters as human nonpancreatic secretory phospholipase A(2) inhibitors.生物有机化学与医药化学.
MLA	Wu, Yiran,et al."Quinoline-4-methyl esters as human nonpancreatic secretory phospholipase A(2) inhibitors".生物有机化学与医药化学 (2011).