Thermoresponsive Gene Carriers Based on   Polyethylenimine-graft-Poly[oligo(ethylene glycol) methacrylate]

doi:10.1002/mabi.201100094

CORC > 北京大学 > 化学与分子工程学院

	Thermoresponsive Gene Carriers Based on Polyethylenimine-graft-Poly[oligo(ethylene glycol) methacrylate]
	Zhang, Rui ; Wang, Yang ; Du, Fu-Sheng ; Wang, Ying-Li ; Tan, Ying-Xia ; Ji, Shou-Ping ; Li, Zi-Chen
刊名	大分子生物学
	2011
关键词	cationic gene carriers hyperthermia polyethylenimine poly[oligo(ethylene glycol) methacrylate] thermoresponsive TRANSFECTION EFFICIENCY IN-VITRO THERMOSENSITIVE POLYMERS BLOCK-COPOLYMERS DNA COMPLEXATION DELIVERY VECTORS TRANSFER AGENTS TEMPERATURE POLYETHYLENIMINE NANOPARTICLES
DOI	10.1002/mabi.201100094
英文摘要	A family of thermoresponsive cationic copolymers (TCPs) that contain branched PEI 25 K as the cationic segment and poly(MEO(2)MA-co-OEGMA(475)) as the thermosensitive block (TP) is prepared. The DNA binding capability, physicochemical properties, and biological performance of the TCPs are studied. All of these TCPs can condense DNA to form polyplexes with diameters of 150-300nm and zeta potentials of 7-32mV at N/P ratios between 12 and 36. The length of TP block is a key factor for shielding the positive surface charge of the polyplexes and protecting them against protein adsorption. TCPs with a higher TP content have a lower cytotoxicity while the best transfection performance is achieved by the TCPs with longest TP length, reaching a level of the intact PEI 25 K in the presence of serum.; Biochemistry & Molecular Biology; Materials Science, Biomaterials; Polymer Science; SCI(E); EI; PubMed; 1; ARTICLE; 10; 1393-1406; 11
语种	英语
内容类型	期刊论文
源URL	[http://ir.pku.edu.cn/handle/20.500.11897/149946]
专题	化学与分子工程学院
推荐引用方式 GB/T 7714	Zhang, Rui,Wang, Yang,Du, Fu-Sheng,et al. Thermoresponsive Gene Carriers Based on Polyethylenimine-graft-Poly[oligo(ethylene glycol) methacrylate][J]. 大分子生物学,2011.
APA	Zhang, Rui.,Wang, Yang.,Du, Fu-Sheng.,Wang, Ying-Li.,Tan, Ying-Xia.,...&Li, Zi-Chen.(2011).Thermoresponsive Gene Carriers Based on Polyethylenimine-graft-Poly[oligo(ethylene glycol) methacrylate].大分子生物学.
MLA	Zhang, Rui,et al."Thermoresponsive Gene Carriers Based on Polyethylenimine-graft-Poly[oligo(ethylene glycol) methacrylate]".大分子生物学 (2011).